公开(公告)号：US20070298006A1

公开(公告)日：2007-12-27

申请号：US11630044

申请日：2005-12-21

申请人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang ,  Veera Pulgam ,  Sonke Svenson ,  Lori Reyna ,  Michael Zhuravel ,  Abhay Chauhan ,  Cordell DeMattei ,  Joseph Heinzelmann

发明人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang ,  Veera Pulgam ,  Sonke Svenson ,  Lori Reyna ,  Michael Zhuravel ,  Abhay Chauhan ,  Cordell DeMattei ,  Joseph Heinzelmann

IPC分类号： A61K31/785 ,  A61K31/74 ,  A61K47/30 ,  A61K48/00 ,  B05D3/12 ,  C08G63/48 ,  C08G65/329 ,  C08K3/04 ,  C08K3/22 ,  C12N15/87

CPC分类号： C08G63/46 ,  A01N25/10 ,  A61K8/85 ,  A61K9/0019 ,  A61K9/5146 ,  A61Q15/00 ,  A61Q17/005 ,  C08G83/003 ,  H01M4/86 ,  H01M8/10 ,  Y02P70/56

摘要： Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.

摘要翻译： 公开了具有增强的扩增和内部功能的树枝状聚合物。 这些树枝状聚合物通过使用快速，反应性开环化学（或其他快速反应）结合使用分支细胞试剂以受控方式快速和精确地构建树突状结构，一代代，具有更清洁的化学，通常 单一产品，较低的试剂过量，较低的稀释水平，更高的容量方法，更容易缩放到商业尺寸，新的材料范围以及更低的成本。 制备的树枝状组合物具有新颖的内部功能，更高的稳定性（例如，热稳定性和较少的或没有反向的迈克尔反应），并且在较低的代次下达到包封表面密度。 出乎意料的是，多官能分支细胞试剂与多官能核心的这些反应不产生交联材料。 这种树枝状聚合物可用作油/水乳液的破乳剂，纸张制造中的湿强剂，质子清除剂，聚合物，纳米尺寸单体，用于电子显微镜的校准标准品，制备尺寸选择性膜，以及用于在水性制剂中改性粘度的试剂 作为油漆。 当这些树枝状聚合物具有与其表面和/或内部相关的载体材料时，由于树枝状聚合物的独特特征，例如用于药物递送，转染和诊断，这些树枝状聚合物具有携带材料的附加性质。

公开(公告)号：US20060160988A1

公开(公告)日：2006-07-20

申请号：US10543671

申请日：2004-01-29

申请人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang

发明人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang

IPC分类号： C08G69/08

CPC分类号： C08G83/003 ,  C08G69/02

摘要： Heterocycle terminated dendritic polymers. More specifically, the production of 2-pyrrolidone, 2-piperidone, 2-aza-cycloheptanone or 2-azetidinone-terminated dendritic polymers obtained by reacting precursor primary amine, (e.g., —NH2)-terminated dendritic polymers with certain functionalized methacrylate reagents to produce new and novel dendritic polymers terminated with ester substituted 2-pyrrolidone, 2-piperidone, 2 aza-cycloheptanone or 2-azetidinone groups.

摘要翻译： 杂环封端的树枝状聚合物。 更具体地说，通过使前体伯胺（例如-NH 2 - ）反应而得到的2-吡咯烷酮，2-哌啶酮，2-氮杂 - 环庚酮或2-氮杂环丁酮封端的树枝状聚合物的制备（例如，-NH 2 - 具有某些官能化甲基丙烯酸酯试剂的树枝状聚合物以产生用酯取代的2-吡咯烷酮，2-哌啶酮，2氮杂 - 环庚酮或2-氮杂环丁酮基团封端的新型和新颖的树枝状聚合物。

公开(公告)号：US20070244296A1

公开(公告)日：2007-10-18

申请号：US10594776

申请日：2005-04-20

申请人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang ,  Veera Pulgam

发明人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang ,  Veera Pulgam

IPC分类号： C08J3/00 ,  C08J9/32 ,  C08J9/40 ,  C08K9/00

CPC分类号： C08G83/003 ,  C08G59/1477 ,  C08G59/32 ,  C08G59/3227 ,  C08G59/5026

摘要： Poly(ester-acrylate) and poly(ester/epoxide) dendrimers. These materials can be synthesized by utilizing the so-called “sterically induced stoichiometric” principles. The preparation of the dendrimers is carried out by reacting precursor amino/polyamino-functional core materials with various branch cell reagents. The branch cell reagents are dimensionally large, relative to the amino/polyamino-initiator core and when reacted, produce generation=1 dendrimers directly in one step. There is also a method by which the dendrimers can be stabilized and that method is the reaction of the dendrimers with surface reactive molecules to pacify the reactive groups on the dendrimers.

摘要翻译： 聚（酯 - 丙烯酸酯）和聚（酯/环氧化物）树枝状大分子。 这些材料可以通过利用所谓的“空间诱导化学计量”原理来合成。 树枝状大分子的制备通过使前体氨基/聚氨基官能的核心材料与各种分支细胞试剂反应来进行。 分支细胞试剂相对于氨基/聚氨基 - 引发剂核心在尺寸上是大的，并且当反应时，在一个步骤中直接产生生成= 1个树枝状大分子。 还有一种树枝状聚合物可以稳定的方法，该方法是树枝状聚合物与表面反应性分子的反应，以平衡树枝状聚合物上的反应性基团。

公开(公告)号：US20070073004A1

公开(公告)日：2007-03-29

申请号：US10568481

申请日：2004-09-10

申请人： Donald Tomalia ,  Douglas Swanson

发明人： Donald Tomalia ,  Douglas Swanson

IPC分类号： C08F120/10

CPC分类号： C08F220/18 ,  C07C229/16 ,  C07C233/36 ,  C08G83/005

摘要： Methods of providing hyperbranched polymers by polymerization of appropriate AB2 monomers derived from the reaction of tris-(2-aminoethyl) amine and various other materials, namely, succinic anhydride, methyl acrylate, and dimethyl ita-conate.

摘要翻译： 通过聚合衍生自三 - （2-氨基乙基）胺和各种其它材料即琥珀酸酐，丙烯酸甲酯和二甲基甲酸酯的各种其他材料的合适的AB 2 H 2单体提供超支化聚合物的方法 。

公开(公告)号：US20050171298A1

公开(公告)日：2005-08-04

申请号：US10767567

申请日：2004-01-29

申请人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang

发明人： Donald Tomalia ,  Douglas Swanson ,  Baohua Huang

IPC分类号： C08G69/08

CPC分类号： C08G83/003 ,  Y10T428/31786

摘要： Heterocycle terminated dendritic polymers. More specifically, the production of 2-pyrrolidone, 2-piperidone, 2-aza-cycloheptanone or 2-azetidinone-terminated dendritic polymers obtained by reacting precursor primary amine,(e.g., —NH2)-terminated dendritic polymers with certain functionalized methacrylate reagents to produce new and novel dendritic polymers terminated with ester substituted 2-pyrrolidone, 2-piperidone, 2-aza-cycloheptanone or 2-azetidinone groups.

摘要翻译： 杂环封端的树枝状聚合物。 更具体地说，通过使前体伯胺（例如-NH 2 - ）末端反应而得到的2-吡咯烷酮，2-哌啶酮，2-氮杂 - 环庚酮或2-氮杂环丁酮封端的树枝状聚合物的制备 具有某些官能化甲基丙烯酸酯试剂的树枝状聚合物以产生用酯取代的2-吡咯烷酮，2-哌啶酮，2-氮杂 - 环庚酮或2-氮杂环丁酮基团封端的新型和新颖的树枝状聚合物。

公开(公告)号：US20050038197A1

公开(公告)日：2005-02-17

申请号：US10639939

申请日：2003-08-13

申请人： Donald Tomalia ,  Douglas Swanson

发明人： Donald Tomalia ,  Douglas Swanson

IPC分类号： C08F271/02 ,  C08G20060101 ,  C08G83/00

CPC分类号： C08G83/002 ,  C08G83/005

摘要： Mono-reactive dendrigrafts prepared by convergent self-branching polymerization and their subsequent grafting to linear, dendritic, and dendrigraft, branched, and hyper-branched substrates to prepare ultra-high molecular weight dendrigraft architectures using alkyl halides and aryl halides as initiators.

摘要翻译： 通过会聚自支化聚合制备的单反应性树枝状体，并且随后将其接枝到线性，树枝状和树枝状结构，支化和超分支底物，以制备使用烷基卤和芳基卤化物作为引发剂的超高分子量树枝状结构。

公开(公告)号：US20060039891A1

公开(公告)日：2006-02-23

申请号：US10493354

申请日：2001-10-29

申请人： Navid Malik ,  Ruth Duncan ,  Donald Tomalia ,  Roseita Esfand

发明人： Navid Malik ,  Ruth Duncan ,  Donald Tomalia ,  Roseita Esfand

IPC分类号： A61K31/765

CPC分类号： A61K31/765

摘要： Antineoplastic dendritic polymer conjugates which are useful drug delivery systems for carrying antineoplastic agents to malignant tumors are prepared. The antineoplastic agent is encapsulated within the dendritic polymer using an ionic charge shunt mechanism, whereby, the antineoplastic agent interacts with the anionic functional groups on the surface of the dendritic polymer allowing the antineoplastic agent to be uptaken by the dendritic polymer through an association with the functional groups of the interior of the dendritic polymer. The antineoplastic dendritic polymer conjugates may be administered intravenously, orally, parentally, subcutaneously, intraarterially or topically to an animal having a malignant tumor in an amount which is effective to inhibit growth of the malignant tumor. The antineoplastic dendritic polymer conjugates exhibit high drug efficiency, high drug carrying capacity, good water solubility, good stability on storage, and reduced toxicity.

摘要翻译： 制备用于将抗肿瘤药物携带到恶性肿瘤中的有用的药物递送系统的抗肿瘤树突状聚合物缀合物。 使用离子电荷分流机制将抗肿瘤剂包封在树突状聚合物内，由此，抗肿瘤剂与树突状聚合物表面上的阴离子官能团相互作用，允许抗肿瘤剂被树状聚合物吸收，通过与 树枝状聚合物内部的官能团。 抗肿瘤性树突状聚合物缀合物可以以有效抑制恶性肿瘤生长的量静脉内，口服，亲本，皮下，动脉内或局部给予具有恶性肿瘤的动物。 抗肿瘤树突状聚合物缀合物具有药效高，药物携带能力强，水溶性好，储存稳定性好，毒性降低。

公开(公告)号：US07389029B2

公开(公告)日：2008-06-17

申请号：US10710303

申请日：2004-07-01

申请人： Anis Rahman ,  Donald Tomalia

发明人： Anis Rahman ,  Donald Tomalia

IPC分类号： G02B6/10

CPC分类号： B82Y30/00 ,  G02B6/1221

摘要： The present invention discloses a photonic waveguide that is based on natural index contrast (NIC) principle and also discloses fabrication details thereof. Such waveguide forms the basis of a class of chip-scale micro- and nano-photonic integrated circuits (PICs). The NIC method utilizes the built-in refractive index difference between two layers of dielectric thin films of two materials, created from nano-materials that are designed for optical waveguide applications. This new class of waveguides simplifies the PIC fabrication process significantly. Based on the NIC based waveguides, which by design possess multiple photonic functionalities, PICs can be fabricated for a number of photonic applications such as arrayed waveguide grating (AWG), reflective arrayed waveguide grating (RAWG), interleaver, interferometer, and electro-optic sensor. Additionally, several other PICs can also be fabricated via tiers of integration, such as triple-phase integration where multiple optical functionalities are monolithically integrated on a chip.

摘要翻译： 本发明公开了一种基于自然指数对比（NIC）原理的光子波导，并且还公开了其制造细节。 这种波导形成了一类芯片级微型和纳米光子集成电路（PIC）的基础。 NIC方法利用由针对光波导应用设计的纳米材料制成的两层材料的两层介电薄膜之间的内置折射率差异。 这种新类型的波导显着简化了PIC制造工艺。 基于基于NIC的波导，其通过设计具有多个光子功能，可以为许多光子应用制造PIC，例如阵列波导光栅（AWG），反射阵列波导光栅（RAWG），交织器，干涉仪和电光 传感器。 此外，还可以通过集成层级来制造其他几种PIC，例如其中多个光学功能单片集成在芯片上的三相集成。

公开(公告)号：US20060177376A1

公开(公告)日：2006-08-10

申请号：US10565478

申请日：2004-07-21

申请人： Donald Tomalia ,  Boahua Huang

发明人： Donald Tomalia ,  Boahua Huang

IPC分类号： A61F2/00

CPC分类号： C09K11/025 ,  B22F1/0018 ,  B22F1/0074 ,  B22F2998/00 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y30/00 ,  C01B19/007 ,  C09K11/565 ,  C09K11/883 ,  B22F1/0022

摘要： Dendronization of nano-scale surfaces with focal point reactive dendrons to produce stabilized chemically functionalized nano-particles having quantum dot dimensions.

摘要翻译： 具有焦点反应性枝晶的纳米级表面的树突化以产生具有量子点尺寸的稳定的化学官能化纳米颗粒。

公开(公告)号：US20060160929A1

公开(公告)日：2006-07-20

申请号：US11384910

申请日：2006-03-21

申请人： Donald Tomalia ,  Lajos Balogh

发明人： Donald Tomalia ,  Lajos Balogh

IPC分类号： C08J9/32

CPC分类号： C08J3/20 ,  C08G83/003 ,  Y10S977/754

摘要： In the present invention, an inorganic reactant is, or reactants are, localized with respect to a dendritic polymer by physical constraint within or by a non-covalent conjugation to the dendritic polymer. The localized inorganic reactant or reactants is/are subsequently transformed to form a reaction product which is immobilized with respect to the dendritic polymer. This immobilization occurs on a nanoscopic scale as a consequence of the combined effects of structural, chemical and physical changes without having covalent bonds between the product(s) and the dendritic container and results in new compositions of matter called dendritic nanocomposites. The resulting nanocomposite material can be used to produce revolutionary products such as water soluble elemental metals, with specific applications including magnetic resonance imaging, catalytic, magnetic, optical, photolytic and electroactive applications.