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公开(公告)号:US07176195B2
公开(公告)日:2007-02-13
申请号:US10311301
申请日:2001-06-21
申请人: Doreen Ashworth , Gary R. W. Pitt , Peter Hudson , Christopher Yea , Richard J. Franklin , Graeme Semple , David Paul Jenkins
发明人: Doreen Ashworth , Gary R. W. Pitt , Peter Hudson , Christopher Yea , Richard J. Franklin , Graeme Semple , David Paul Jenkins
IPC分类号: A61P7/12 , A61K31/55 , C07D487/00 , C07D498/00 , C07D513/00
CPC分类号: C07D223/16 , C07D243/12 , C07D267/14 , C07D281/10 , C07D401/06 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要: Compounds according to general formulae (1 and 2), wherein G1 is an azepine derivative and G2 is a group according to general formulae (9–11) are new. Compounds according to the invention are vasopressin V2 receptor agonists. Pharmaceutical compositions of the compounds are useful as antidiuretic agents
摘要翻译: 根据通式(1和2)的化合物,其中G 1是吖庚因衍生物,而G 2是根据通式(9-11)的基团。 根据本发明的化合物是加压素V 2 O 2受体激动剂。 化合物的药物组合物可用作抗利尿剂