公开(公告)号：US20140309443A1

公开(公告)日：2014-10-16

申请号：US14000519

申请日：2012-02-24

申请人： Douglas Covey ,  Eva Kudcva

发明人： Douglas Covey ,  Eva Kudcva

IPC分类号： C07J41/00

CPC分类号： C07J41/0094 ,  C07J1/0011 ,  C07J3/00 ,  C07J7/002 ,  C07J13/005 ,  C07J21/008

摘要： The present disclosure is generally directed to neuroactive 17(20)-Z-vinylcyano-substituted compound of Formula (I) and (II), as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

摘要翻译： 本公开一般涉及本文所提及的式（I）和（II）的神经活性的17（20）-Z-乙烯基氰取代的化合物及其药学上可接受的盐，用作例如麻醉剂，和 /或治疗与GABA功能和活动相关的疾病。 本公开进一步涉及包含这些化合物的药物组合物。