公开(公告)号：US07387895B2

公开(公告)日：2008-06-17

申请号：US10543452

申请日：2003-10-16

申请人： Doyoung Yoon ,  Haesook Lee ,  Minchul Cho ,  Kyungae Lee ,  Kyungjoo Cho ,  Jeongwoo Kang ,  Junghyun Shim ,  Jongseok Lim ,  Jintae Hong ,  Heegu Lee ,  Yongkyung Choe

发明人： Doyoung Yoon ,  Haesook Lee ,  Minchul Cho ,  Kyungae Lee ,  Kyungjoo Cho ,  Jeongwoo Kang ,  Junghyun Shim ,  Jongseok Lim ,  Jintae Hong ,  Heegu Lee ,  Yongkyung Choe

IPC分类号： C12N5/06

CPC分类号： C07K16/2857 ,  G01N33/57496 ,  G01N33/6875 ,  G01N33/743 ,  G01N2500/00 ,  G01N2500/02

摘要： The present invention relates to a hybridoma cell line producing a PPAR gamma-specific monoclonal antibody, and a method for detecting a PPAR gamma ligand related to the progression of difficult diseases, such as cancer, inflammation and metabolic diseases obesity and diabetes), using the PPAR gamma-specific monoclonal antibody. This PPAR gamma-specific monoclonal antibody and the method for screening a PPAR gamma ligand using the monoclonal antibody will be commercially used for screening a PPAR gamma regulator related to diseases such as inflammatory, cancer and metabolic diseases, and also will serve as an useful tool for analyzing the function of such a ligand.

摘要翻译： 本发明涉及产生PPARγ特异性单克隆抗体的杂交瘤细胞系和检测与恶性疾病如癌症，炎症和代谢疾病肥胖症和糖尿病等进展有关的PPARγ配体的方法），使用 PPARγ特异性单克隆抗体。 该PPARγ特异性单克隆抗体和使用单克隆抗体筛选PPARγ配体的方法将被商业用于筛选与疾病如炎症，癌症和代谢疾病相关的PPARγ调节剂，并且还将用作有用的工具 用于分析这种配体的功能。