公开(公告)号：US20240041986A1

公开(公告)日：2024-02-08

申请号：US18028634

申请日：2021-10-05

申请人： Dr. Mary Morris & Associates, LLC ,  Saint Louis University

发明人： Mary S. Morris ,  Richard J. DiPaolo

IPC分类号： A61K38/28 ,  A61K47/02 ,  A61K47/10 ,  A61P3/10

CPC分类号： A61K38/28 ,  A61K47/02 ,  A61K47/10 ,  A61P3/10

摘要： Methods of attenuating an antigenic response in a mammal to one or more Type 1 diabetes related-antigens are provided. The method may result in delaying the onset of decreased pancreatic beta cell function in the mammal and/or at least delaying a reduction in serum C-peptide levels in the mammal The method comprises sublingually administering an effective amount of an insulin-related peptide to the mammal and commonly makes use of a sublingual formulation of an insulin-related peptide that includes an aqueous pharmaceutically acceptable carrier, e.g., an aqueous carrier which comprises at least about 30 vol. % glycerin.

公开(公告)号：US20230018324A1

公开(公告)日：2023-01-19

申请号：US17778624

申请日：2020-11-25

申请人： Dr. Mary Morris & Associates, LLC

发明人： Mary S. Morris

IPC分类号： A61K38/28 ,  A61K9/00 ,  A61P3/10

摘要： The disclosure provides methods of preventing or treating Type 1 diabetes in a mammalian subject, reducing risk factors associated with Type 1 diabetes, and/or reducing the likelihood or severity of Type 1 diabetes. A method of attenuating an antigenic response in a mammal to at least one Type 1 diabetes related-antigen is also provided. The methods include sublingually administering an effective amount of an insulin-related peptide to a subject.