-
公开(公告)号：US20180073000A1
公开(公告)日：2018-03-15
申请号：US15411797
申请日：2017-01-20
IPC分类号： C12N9/16
CPC分类号： C12N9/16 , A61K38/00 , C12Y301/06004
摘要： Disclosed are methods and compositions for reduced immunogenic proteins used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are genetically engineered variants of N-acetylgalactosamine-6-sulfatase (GALNS), which are less immunogenetic then wild-type GALNS, but maintain enzymatic activity, and may be used to treat Mucopolysaccharidosis IVA (Morquio A disease, MPS IVA).
-
公开(公告)号：US10472615B2
公开(公告)日：2019-11-12
申请号：US15411797
申请日：2017-01-20
摘要： Disclosed are methods and compositions for reduced immunogenic proteins used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are genetically engineered variants of N-acetylgalactosamine-6-sulfatase (GALNS), which are less immunogenetic then wild-type GALNS, but maintain enzymatic activity, and may be used to treat Mucopolysaccharidosis IVA (Morquio A disease, MPS IVA).
-
公开(公告)号：US11969460B2
公开(公告)日：2024-04-30
申请号：US17054740
申请日：2019-06-04
摘要： Disclosed are methods and compositions for treating cognitive decline in subjects in need. More specifically, disclosed are methods of administrating exogenous adropin to subjects suffering from, or at risk of, cognitive decline. Also disclosed are subjects who would benefit from such treatment and pharmaceutical acceptable compositions comprising adropin, adropin34-76, and derivatives or variations thereof.
-
公开(公告)号：US11844825B2
公开(公告)日：2023-12-19
申请号：US17314510
申请日：2021-05-07
发明人： Adriana M. Montaño-Suarez , Angela Catalina Sosa-Molano , Alan Knutsen , Clifford Bellone , Shunji Tomatsu , Luis Barrera
CPC分类号： A61K38/465 , A61K9/0019 , A61K9/0053 , C12Y301/06004
摘要： Disclosed are methods and compositions for determining immunodominant peptides of target enzymes used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are immunodominant peptides for N-acetylgalactosamine-6-sulfatase (GALNS). Also disclosed are methods of inducing oral tolerance towards a target enzyme through oral administration of immunodominant peptides prior to commencing enzyme replacement therapy. More specifically disclosed is a method of inducing oral tolerance for GALNS, by orally administering specific immunodominant peptides for GALNS; in subjects suffering from mucopolysaccharidosis type IVA prior to commencing enzyme replacement therapy using GALNS.
-
公开(公告)号：US11746097B2
公开(公告)日：2023-09-05
申请号：US16311941
申请日：2017-06-23
IPC分类号： C07D401/04 , C07D217/26 , C07D401/12 , C07D217/06 , C07D417/04 , C07D409/04 , C07D215/38 , A61K9/00
CPC分类号： C07D401/04 , C07D215/38 , C07D217/06 , C07D217/26 , C07D401/12 , C07D409/04 , C07D417/04 , A61K9/0019 , A61K9/0053
摘要： In some aspects, the present disclosure provides compounds of the formula: (I) or (II) wherein the variables are as defined herein. In some embodiments, these compounds may be used to treat cancer or other hyperproliferative diseases, as well as atherosclerosis and coronary artery disease.
-
公开(公告)号：US20230153062A1
公开(公告)日：2023-05-18
申请号：US17996881
申请日：2021-04-21
发明人： Richard D. Bucholz
CPC分类号： G06F3/167 , G06F3/038 , G06F3/023 , G06V20/60 , G10L15/22 , G10L15/30 , G10L25/57 , G06V2201/02 , G10L2015/223
摘要： Provided herein are systems and methods to verbally control a host computer for data entry into the computer, such as for electronic medical record data entry. The verbal interface system may be operable to receive, via a connection interface, at least one video capture of the host computer display; analyze the at least one video capture to determine a plurality of data entry fields displayed on the host computer display; receive, via a microphone, a verbal command correlating to at least one of the plurality of data entry fields; and autonomously control the mouse and/or the keyboard to perform mouse and/or text input into the host computer.
-
公开(公告)号：US11085031B2
公开(公告)日：2021-08-10
申请号：US16097485
申请日：2017-04-28
IPC分类号： C12N9/74 , A61K9/00 , C07K14/745 , C12N15/62 , A61P7/02 , A61K38/36 , A61K38/48 , A61K45/06 , A61K38/00
摘要： Compositions and methods for regulating the blood coagulation pathway are disclosed. More particularly, the present disclosure relates to thrombin-thrombomodulin fusion proteins and their use as blood anticoagulants and for treating sepsis.
-
公开(公告)号：US20210222104A1
公开(公告)日：2021-07-22
申请号：US16094086
申请日：2017-04-18
摘要： Disclosed are fluidic devices and methods for preparing fluidic devices. More particularly, disclosed are fluidic devices having fiber scaffolds and methods for their preparation. Also disclosed are methods for culturing cells using the fluidic devices having fiber scaffolds.
-
公开(公告)号：US20210100932A1
公开(公告)日：2021-04-08
申请号：US16499384
申请日：2018-03-30
发明人： Koyal Garg , Scott A. Sell , Krishna Patel , Hady Elmashhady , Emily Kalaf
摘要： Disclosed are electrospun scaffolds and methods of making electrospun fibers and electrospun fiber scaffolds. More particularly, the present disclosure relates to electrospun fibrous scaffolds of decellularized muscle tissue and methods of making fibers and fiber scaffolds by electrospinning.
-
公开(公告)号：US20210024489A1
公开(公告)日：2021-01-28
申请号：US16936951
申请日：2020-07-23
申请人： Saint Louis University , The United States of America, as represented by the Secretary, Dept. of Health and Human Services
IPC分类号： C07D401/10 , C07K16/28 , C07D211/34 , A61P25/02
摘要： Disclosed herein are methods for treating neuropathic pain in a subject in need thereof. The methods include: administering to a subject in need thereof a therapeutically effective amount of an antagonist of P2Y14.
-
-
-
-
-
-
-
-
-
搜索结果
211 条记录 (耗时 0.025 秒)
