公开(公告)号：US20040132638A1

公开(公告)日：2004-07-08

申请号：US10638969

申请日：2003-08-11

Applicant: Duke University

Inventor： Jonathan S. Stamler ,  Andrew J. Gow

IPC: A61K038/42

CPC classification number: A61K31/00 ,  A61K31/04 ,  A61K31/095 ,  A61K31/195 ,  A61K35/18 ,  A61K38/00 ,  A61K38/44 ,  A61K47/6445 ,  A61K47/6901 ,  C07K14/00 ,  C07K14/805 ,  G01N21/631 ,  G01N21/76 ,  G01N33/721 ,  Y10T436/105831

Abstract: Nitrosylhemoglobin can be produced by introducing gaseous NO into an aqueous solution of hemoglobin. It has been demonstrated that nitrosylhemoglobin in aqueous solution can be converted to SNO-hemoglobin upon introduction of oxygen to the solution, as is postulated to occur in the lungs. Nitrosylhemoglobin can be used in methods to produce the physiological effects of NO, for example, to reduce vasoconstriction and to inhibit platelet aggregation.

Abstract translation: 可以通过将气态NO引入血红蛋白水溶液中来产生亚硝基血红蛋白。 已经证明，如将假定在肺中发生的那样将氧气引入溶液中，则可将水溶液中的亚硝基血红蛋白转化为SNO-血红蛋白。 硝基血红蛋白可用于产生NO的生理作用的方法，例如减少血管收缩和抑制血小板聚集。