公开(公告)号：US20170037471A1

公开(公告)日：2017-02-09

申请号：US15106873

申请日：2014-12-23

Applicant: Duke University

Inventor： Dennis J. Thiele ,  Byung-Eun Kim

IPC: C12Q1/68 ,  A61K33/34

CPC classification number: C12Q1/6883 ,  A61K33/34 ,  C12Q2600/118 ,  C12Q2600/156

Abstract: Described are methods and materials for diagnosing a subject's predisposition for cardiovascular disease by detecting a copper deficiency genetic marker, as well as methods of alleviating Cu transport impairment. Specifically, the Cu deficiency genetic marker may be within the gene encoding a transmembrane Cu transporter protein (Ctri) or its regulatory sequences.

Abstract translation: 描述了通过检测铜缺乏遗传标记来诊断受试者心血管疾病倾向的方法和材料，以及减轻铜转运损伤的方法。 具体地说，Cu缺陷遗传标记可能在编码跨膜Cu转运蛋白（Ctri）或其调控序列的基因内。