公开(公告)号：US20030078365A1

公开(公告)日：2003-04-24

申请号：US10164366

申请日：2002-06-05

Applicant: Duke University

Inventor： Jonathan S. Stamler ,  Eric J. Toone ,  Richard S. Stack

IPC: C08G075/00

CPC classification number: A61K31/785 ,  A61K47/61 ,  A61K47/6951 ,  A61L29/10 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/42 ,  B82Y5/00 ,  C08B37/0012 ,  C08G75/00 ,  C08L5/16 ,  C09D105/16 ,  G06F19/00 ,  Y10T428/1393

Abstract: Disclosed are novel polymers derivatized with at least one nullSNO group per 1200 atomic mass unit of the polymer. In one embodiment, the S-nitrosylated polymer has stabilized nullS-nitrosyl groups. In another embodiment the S-nitrosylated polymer prepared by polymerizing a compound represented by the following structural formula: 1 R is an organic radical. Each Xnull is an independently chosen aliphatic group or substituted aliphatic group. Preferably, each Xnull is the same and is a C2-C6 alkylene group, more preferably nullCH2null, nullCH2CH2null, nullCH2CH2CH2null or nullCH2CH2CH2CH2null. p and m are independently a positive integer such that pnullm is greater than two. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.

Abstract translation: 公开了每聚合物的每1200原子质量单位衍生自至少一个-SNO基团的新型聚合物。 在一个实施方案中，S-亚硝基化聚合物具有稳定的-S-亚硝酰基。 在另一个实施方案中，通过聚合由以下结构式表示的化合物制备的S-亚硝基化聚合物：R是有机基团。 每个X'是独立选择的脂族基团或取代的脂族基团。 优选地，每个X'相同且为C2-C6亚烷基，更优选为-CH2-，-CH2CH2-，-CH2CH2CH2-或-CH2CH2CH2CH2-。 p和m独立地为正整数，使得p + m大于2。 本发明的聚合物可用于涂覆医疗装置以将体内的一氧化氮输送到治疗部位。

公开(公告)号：US20040132904A1

公开(公告)日：2004-07-08

申请号：US10668667

申请日：2003-09-23

Applicant: Duke University

Inventor： Jonathan S. Stamler ,  Eric J. Toone ,  Richard S. Stack

IPC: C08B037/16 ,  C08G083/00

CPC classification number: A61K31/785 ,  A61K47/61 ,  A61K47/6951 ,  A61L29/10 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L33/068 ,  A61L33/08 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/42 ,  B82Y5/00 ,  C08B37/0012 ,  C08G75/00 ,  C08L5/16 ,  C09D105/16 ,  G06F19/00 ,  Y10T428/1393

Abstract: Disclosed are novel polymers derivatized with at least one nullNOx group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.

Abstract translation: 公开了以聚合物的每1200原子质量单位至少一个-NO x基团衍生的新型聚合物。 X是一两个。 在一个实施方案中，聚合物是S-亚硝基化的聚合物，并且通过使多硫醇化聚合物与亚硝酰化剂在适于亚硝酰化游离巯基的条件下反应来制备。 本发明的聚合物可用于涂覆医疗装置以将体内的一氧化氮输送到治疗部位。