公开(公告)号：US20180318337A1

公开(公告)日：2018-11-08

申请号：US15773933

申请日：2016-11-04

Applicant: Duke University

Inventor： Bruce A. Sullenger ,  Ibtehaj Naqvi ,  Ruwan Gunaratne ,  Rebekah White

IPC: A61K31/785 ,  A61K9/00 ,  A61P35/04 ,  C12Q1/6886

CPC classification number: A61K31/785 ,  A61K9/0012 ,  A61K31/724 ,  A61K31/80 ,  A61P35/04 ,  C08L57/12 ,  C08L2203/02 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: Methods of treating cancer in a subject by administering a therapeutically effective amount of a polycationic polymer to the subject are provided. Methods of treating cancer in a subject by contacting a bodily fluid from a subject with a polycationic polymer are also provided. Methods of detecting cancer or metastasis of cancer by obtaining a sample from a subject and determining the level of circulating free DNA (cfDNA), cfRNA, inorganic polyphosphates or the number of exosomes or nucleosomes in the sample are also provided.