公开(公告)号：US11613756B2

公开(公告)日：2023-03-28

申请号：US16499991

申请日：2018-04-03

Applicant: Duke University

Inventor： Jaewoo Lee ,  Bruce A. Sullenger ,  Youngju Lee

IPC: C12N15/117

Abstract: Disclosed herein are compositions and methods for inhibiting the growth of cells or inducing cell death. The composition capable of inhibiting the growth of cells or inducing cell death comprises a 5′-triphosphate non-linear RNA. The RNA comprises a first stem-loop formed from the complete or partial hybridization of at least 8 nucleotide pairings and may optionally comprise a second stem-loop formed from the complete or partial hybridization of at least 8 nucleotide pairings and a spacer between the first stem-loop and the second stem loop. Methods for inhibiting the growth of cells or inducing cell death comprise contacting cells with the composition or administering the composition to a subject in an amount effective to inhibit the growth of the cells or induce death of the cells.

公开(公告)号：US20220168331A1

公开(公告)日：2022-06-02

申请号：US17430991

申请日：2020-02-18

Applicant: Duke University

Inventor： Jaewoo Lee ,  Youngju Lee

IPC: A61K31/713 ,  A61P35/00 ,  A61P37/04 ,  A61K45/06

Abstract: The present disclosure provides nucleic acid molecules, compositions, and pharmaceutical compositions comprising a pattern recognition receptor (PRR) agonist and a microRNA antagonist and methods treating or preventing cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of the nucleic acid molecules, compositions, and pharmaceutical compositions.