公开(公告)号：US20140154241A1

公开(公告)日：2014-06-05

申请号：US13991178

申请日：2011-12-05

申请人： Duncan McGregor ,  William Eldridge ,  Simon Robins ,  Marie Fernie ,  Tricia White ,  Stuart Pritchard ,  Susan King

发明人： Duncan McGregor ,  William Eldridge ,  Simon Robins ,  Marie Fernie ,  Tricia White ,  Stuart Pritchard ,  Susan King

IPC分类号： C07K16/18

CPC分类号： C07K16/18 ,  C07K14/461 ,  C07K2317/20 ,  C07K2317/565 ,  C07K2319/31

摘要： A modified igNAR peptide sequence derived from a wild-type igNAR peptide sequence is diversified by mutating the amino acid sequence at 50% or more of the amino acids in the CDR3 loop region and optionally at 50% or more of the amino acids in the CDR3 loop region. The modified igNAR peptide may have the sequence of SEQ ID NO: 8, 10 or 50 to 85. The modified igNAR peptides have binding activity against albumin protein sequences, such as human serum albumin. These modified igNAR peptides may have utility in extending the in vivo half-life of biological molecules e.g. therapeutic agents, and so may be used in medicine.

摘要翻译： 衍生自野生型igNAR肽序列的修饰的igNAR肽序列通过在CDR3环区域中的任何氨基酸的50％或更多的氨基酸序列突变并且任选地在CDR3中的50％或更多个的氨基酸中变异 循环区域。 修饰的igNAR肽可以具有SEQ ID NO：8,10或50至85的序列。修饰的igNAR肽对白蛋白蛋白序列如人血清白蛋白具有结合活性。 这些修饰的igNAR肽可用于延长生物分子的体内半衰期，例如， 治疗剂等也可用于医药。

公开(公告)号：US08371650B2

公开(公告)日：2013-02-12

申请号：US10704860

申请日：2003-11-07

申请人： Susan King

发明人： Susan King

IPC分类号： A47C31/00

CPC分类号： B60N2/286 ,  B60N2/2839 ,  B60N2/585

摘要： A disposable car seat, vehicle seat or other seat liner that may include: Version A, being sheet material having a top surface of an absorbent material and a bottom surface of non-permeable material; having several line points at the upper middle, lower middle, left and right sides of middle, and left and right sides of upper, outer edges to accept car seat belt hook-ups; an elasticized outer edge; a backing of light adhesive. Version B of invention includes: sheet material of the same qualities as version A; light adhesive backing; line point to accommodate hook-up belt of a protective arm; closure tabs on upper and lower edges. Version C designed for a booster seat, vehicle seat or other seat includes same material, line points and adhesive backing as version A; elasticized edge on central left and right sides that stand up forming a well or barrier.

摘要翻译： 一次性汽车座椅，车辆座椅或其他座椅衬套，其可以包括：版本A，其是具有吸收材料的顶表面和不可渗透材料的底表面的片材; 在中部上下中间，左下两侧，上边缘和外边缘左右两侧有几条线点，以接受汽车安全带连接; 弹性外缘; 光胶的背衬。 发明版本B包括：与A版相同质量的片材; 轻胶背; 线路点以容纳保护臂的连接带; 上边缘和下边缘处的闭合突出部。 专为增压座椅，车座或其他座椅设计的版本C包括与A版相同的材料，线路点和粘合剂背衬; 中心的左侧和右侧的弹性边缘站起来形成井或屏障。