公开(公告)号：US20180362664A1

公开(公告)日：2018-12-20

申请号：US16061103

申请日：2016-12-09

Applicant: Dyax Corp.

Inventor： Burt Adelman ,  Yung Chyung ,  Jennifer Schranz

IPC: C07K16/40 ,  A61K39/395 ,  A61P29/00

Abstract: Provided herein are plasma kallikrein antibodies binding to active plasma kallikrein and methods of using such antibodies in treating and preventing hereditary angioedema attack, such method may involve a first treatment period and optionally, a second treatment period. Also provided are methods of using such antibodies in treating hereditary angioedema involving a single dose of the antibody to a subject who has undergone a prior HAE treatment, followed by multiple doses of the same antibody if the subject experiences an HAE attack after the single dose.