公开(公告)号：US20200340987A1

公开(公告)日：2020-10-29

申请号：US16844463

申请日：2020-04-09

Applicant: Dyax Corp.

Inventor： Priya Sethu Chockalingam ,  Zhiwei Zhou

IPC: G01N33/543 ,  G01N33/58 ,  G01N21/64

Abstract: A device for detecting and/or quantifying functional C1-esterase inhibitor (fC1-INH), the device comprising: (i) a conjugate pad comprising a first zone and a second zone, on which a first agent and a second agent are immobilized, respectively, and (ii) a membrane, which is in communication with the conjugate pad, wherein the membrane comprises a third zone, on which a third agent is immobilized. The conjugate pad may further comprise a fourth zone for placing a biological sample, which flows through the device in the order of the first zone, the second zone, and the third zone.

公开(公告)号：US20200348311A1

公开(公告)日：2020-11-05

申请号：US16849601

申请日：2020-04-15

Applicant: Dyax Corp.

Inventor： Priya Sethu Chockalingam ,  Yongquan Lai ,  Jiang Wu ,  Guodong Zhang ,  Zhiwei Zhou

IPC: G01N33/68

Abstract: Methods for quantitation of fC1-INH from dried blood spot are provided herein. Such methods may comprise spotting and drying a blood sample on a support member, extracting protein from the dried blood sample and measuring the level of fC1-INH in the extracted proteins.