公开(公告)号：US20230072809A1

公开(公告)日：2023-03-09

申请号：US17910332

申请日：2021-03-09

申请人： Dynavax Technologies Corporation ,  Serum Institute of India Private Limited

发明人： John D. CAMPBELL ,  Robert L. COFFMAN ,  Randall N. HYER ,  Robert S. JANSSEN ,  David NOVACK ,  Martin GOHLKE ,  Maureen URBAN ,  Sunil GAIROLA ,  Umesh SHALLIGRAM ,  Manish GAUTUM ,  Harish RAO

IPC分类号： A61K39/02 ,  A61K39/08 ,  A61K39/05 ,  A61K39/13 ,  A61P31/04

摘要： The present disclosure relates to immunogenic compositions comprising tetanus, diphtheria, and acellular pertussis (Tdap) antigens, and a toll-like receptor 9 (TLR9) agonist, such as oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions may further comprise an aluminum salt adjuvant to which the Tdap antigens are adsorbed. The immunogenic compositions are suitable for active booster immunization against tetanus, diphtheria, and pertussis in an individual in need thereof.

公开(公告)号：US20230110516A1

公开(公告)日：2023-04-13

申请号：US17908222

申请日：2021-03-01

申请人： Dynavax Technologies Corporation ,  MEDIGEN VACCINE BIOLOGICS CORPORATION

发明人： John D. CAMPBELL ,  Robert S. JANSSEN ,  David NOVACK ,  Tsun-Yung KUO ,  Charles CHEN ,  Chung-Chin WU ,  Yi-Jiun LIN ,  Meei-Yun LIN ,  Yu-Chi WU

IPC分类号： C07K14/005 ,  A61P31/14 ,  A61K39/215

摘要： The present disclosure relates to immunogenic compositions comprising a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen, and a toll-like receptor 9 (TLR9) agonist, such as an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against a SARS-CoV-2 in an individual in need thereof.

公开(公告)号：US20230218740A1

公开(公告)日：2023-07-13

申请号：US17908221

申请日：2021-03-01

申请人： Dynavax Technologies Corporation

发明人： John D. CAMPBELL ,  Robert S. JANSSEN ,  David NOVACK

IPC分类号： A61K39/215 ,  A61K39/39

CPC分类号： A61K39/215 ,  A61K39/39 ,  A61K2039/55561

摘要： The present disclosure relates to immunogenic compositions comprising a severe acute respiratory syndrome coron-avirus 2 (SARS-CoV-2) antigen, and a toll-like receptor 9 (TLR9) agonist, such as an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against a SARS-CoV-2 in an individual in need thereof.

公开(公告)号：US20230061403A1

公开(公告)日：2023-03-02

申请号：US17910334

申请日：2021-03-09

申请人： Dynavax Technologies Corporation

发明人： John D. CAMPBELL ,  Randall N. HYER ,  Robert S. JANSSEN ,  David NOVACK

IPC分类号： A61K39/25 ,  A61P31/22

摘要： The present disclosure relates to immunogenic compositions comprising a varicella zoster vims (VZV) glycoprotein E antigen and a toll-like receptor 9 (TLR9) agonist, such as an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against VZV in an individual in need thereof.