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公开(公告)号：US09387247B2
公开(公告)日：2016-07-12
申请号：US14244405
申请日：2014-04-03
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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公开(公告)号：US10441655B2
公开(公告)日：2019-10-15
申请号：US15288545
申请日：2016-10-07
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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公开(公告)号：US11072664B2
公开(公告)日：2021-07-27
申请号：US16503196
申请日：2019-07-03
IPC分类号： C07K16/28 , C07K14/715 , C07K16/00 , C07K14/705 , C07K14/56
摘要： The present invention provides isolated human monoclonal antibodies that bind to IFNAR-1 and that are capable of inhibiting the biological activity of Type I interferons. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting Type I interferon-mediated disorders using the antibodies of the invention, including methods for treating autoimmune disorders, transplant rejection or Graft Versus Host Disease using the antibodies of the invention.
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公开(公告)号：US20140348743A1
公开(公告)日：2014-11-27
申请号：US14248462
申请日：2014-04-09
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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5.发明申请METHODS FOR TREATING CANCER USING ANTI-PD-1 ANTIBODIES IN COMBINATION WITH ANTI-CTLA-4 ANTIBODIES 有权使用抗-PD-1抗体联合抗CTLA-4抗体治疗癌症的方法公开(公告)号：US20140212422A1
公开(公告)日：2014-07-31
申请号：US14227733
申请日：2014-03-27
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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公开(公告)号：US09492540B2
公开(公告)日：2016-11-15
申请号：US14270750
申请日：2014-05-06
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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公开(公告)号：US09492539B2
公开(公告)日：2016-11-15
申请号：US14248462
申请日：2014-04-09
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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公开(公告)号：US20150165025A1
公开(公告)日：2015-06-18
申请号：US14547026
申请日：2014-11-18
发明人： Alan J. KORMAN , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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9.发明授权Methods for treating cancer using anti-PD-1 antibodies in combination with anti-CTLA-4 antibodies 有权使用抗-PD-1抗体与抗CTLA-4抗体组合治疗癌症的方法公开(公告)号：US09358289B2
公开(公告)日：2016-06-07
申请号：US14227733
申请日：2014-03-27
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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公开(公告)号：US09084776B2
公开(公告)日：2015-07-21
申请号：US14547026
申请日：2014-11-18
发明人： Alan J. Korman , Mohan Srinivasan , Changyu Wang , Mark J. Selby , Bingliang Chen , Josephine M. Cardarelli , Haichun Huang
IPC分类号： A61K39/395 , C07K16/28 , A61K39/00
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供以高亲和力特异性结合PD-1的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和感染性疾病）的方法。 本发明还提供了使用组合免疫治疗如抗CTLA-4和抗-PD-1抗体的组合来治疗过度增殖性疾病如癌症的方法。 本发明还提供用于改变与用这种抗体单独治疗相关的不良事件的方法。
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