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公开(公告)号：US10849977B2
公开(公告)日：2020-12-01
申请号：US15903635
申请日：2018-02-23
发明人： Alyssa M. Larson , Kevin Love , Alisha K. Weight , Alan Crane , Robert S. Langer , Alexander M. Klibanov
IPC分类号： A61K39/395 , A61K47/06 , A61K9/19 , C07K16/32 , A61K47/24 , A61K9/00 , A61K47/20 , A61K47/22 , C07K16/22 , C07K16/24 , C07K16/28 , A61K38/00
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-lowering agents that are typically bulky polar organic compounds, such as many of the GRAS (US Food and Drug Administration List of compounds generally regarded as safe) and inactive injectable ingredients and FDA approved therapeutics.
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公开(公告)号：US10646571B2
公开(公告)日：2020-05-12
申请号：US15903523
申请日：2018-02-23
发明人： Alyssa M. Larson , Kevin Love , Alisha K. Weight , Alan Crane , Robert S. Langer , Alexander M. Klibanov
IPC分类号： A61K39/395 , A61K47/06 , A61K9/19 , C07K16/32 , A61K47/24 , A61K9/00 , A61K47/20 , A61K47/22 , C07K16/22 , C07K16/24 , C07K16/28 , A61K47/18 , A61K38/00
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-lowering agents that are typically bulky polar organic compounds, such as many of the GRAS (US Food and Drug Administration List of compounds generally regarded as safe) and inactive injectable ingredients and FDA approved therapeutics.
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公开(公告)号：US20180153997A1
公开(公告)日：2018-06-07
申请号：US15890044
申请日：2018-02-06
发明人： Alyssa M. Larson , Alisha K. Weight , Kevin Love , Alan Crane , Robert S. Langer , Alexander M. Klibanov
IPC分类号： A61K47/06 , C07K16/32 , C07K16/28 , C07K16/24 , C07K16/22 , A61K9/00 , A61K47/22 , A61K47/20 , A61K47/18 , A61K39/395 , A61K47/24 , A61K9/19 , A61K38/00
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous (SC) or intramuscular (IM) injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and organophosphates. The viscosity of the formulation is significantly reduced by the addition of one or more organophosphates.
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4.发明授权公开(公告)号：US10179172B2
公开(公告)日：2019-01-15
申请号：US14483880
申请日：2014-09-11
发明人： Alyssa M. Larson , Kevin Love , Alisha K. Weight , Alan Crane , Robert S. Langer , Alexander M. Klibanov
IPC分类号： A61K39/395 , A61K47/06 , A61K47/24 , A61K9/00 , A61K47/20 , A61K47/22 , C07K16/22 , C07K16/24 , C07K16/28 , A61K47/18 , A61K9/19 , C07K16/32 , A61K38/00
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-lowering water soluble organic dyes.
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公开(公告)号：US20180085463A1
公开(公告)日：2018-03-29
申请号：US15809602
申请日：2017-11-10
发明人： Alyssa M. Larson , Kevin Love , Alisha K. Weight , Alan Crane , Robert S. Langer , Alexander M. Klibanov
IPC分类号： A61K47/06 , C07K16/32 , C07K16/28 , C07K16/24 , C07K16/22 , A61K9/00 , A61K47/22 , A61K47/20 , A61K47/18 , A61K39/395 , A61K47/24 , A61K9/19 , A61K38/00
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-reducing ionic liquids.
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公开(公告)号：US11819550B2
公开(公告)日：2023-11-21
申请号：US17067058
申请日：2020-10-09
发明人： Alyssa M. Larson , Alisha K. Weight , Kevin Love , Alan Crane , Robert S. Langer , Alexander M. Klibanov
IPC分类号： A61K39/395 , A61K47/06 , A61K9/19 , C07K16/32 , A61K47/24 , A61K9/00 , A61K47/20 , A61K47/22 , C07K16/22 , C07K16/24 , C07K16/28 , A61K38/00
CPC分类号： A61K47/06 , A61K9/0019 , A61K9/19 , A61K39/3955 , A61K47/20 , A61K47/22 , A61K47/24 , C07K16/22 , C07K16/241 , C07K16/2839 , C07K16/2863 , C07K16/2887 , C07K16/32 , A61K38/00
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous (SC) or intramuscular (IM) injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and organophosphates. The viscosity of the formulation is significantly reduced by the addition of one or more organophosphates.
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公开(公告)号：US11471479B2
公开(公告)日：2022-10-18
申请号：US15516074
申请日：2015-09-30
发明人： Alyssa M. Larson , Kevin Love , Alisha K. Weight , Alan Crane , Robert S. Langer , Alexander M. Klibanov
IPC分类号： A61K31/727 , A61K31/721 , A61K9/08 , A61K9/19 , A61K9/00 , A61K45/06 , A61K31/715 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K31/722 , A61K31/724 , A61K31/728 , A61K31/734 , A61K31/737 , A61K47/26 , A61K47/36
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of polysaccharides and nucleic acids have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight polysaccharides and nucleic acids, and viscosity-lowering agents.
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公开(公告)号：US10821183B2
公开(公告)日：2020-11-03
申请号：US15809602
申请日：2017-11-10
发明人： Alyssa M. Larson , Kevin Love , Alisha K. Weight , Alan Crane , Robert S. Langer , Alexander M. Klibanov
IPC分类号： A61K39/395 , A61K47/06 , A61K9/19 , C07K16/32 , A61K47/24 , A61K9/00 , A61K47/20 , A61K47/22 , C07K16/22 , C07K16/24 , C07K16/28 , A61K38/00
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-reducing ionic liquids.
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公开(公告)号：US20180177875A1
公开(公告)日：2018-06-28
申请号：US15903523
申请日：2018-02-23
发明人： Alyssa M. Larson , Kevin Love , Alisha K. Weight , Alan Crane , Robert S. Langer , Alexander M. Klibanov
CPC分类号： A61K47/06 , A61K9/0019 , A61K9/19 , A61K38/00 , A61K39/3955 , A61K47/186 , A61K47/20 , A61K47/22 , A61K47/24 , C07K16/22 , C07K16/241 , C07K16/2839 , C07K16/2863 , C07K16/2887 , C07K16/32
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-lowering agents that are typically bulky polar organic compounds, such as many of the GRAS (US Food and Drug Administration List of compounds generally regarded as safe) and inactive injectable ingredients and FDA approved therapeutics.
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公开(公告)号：US20240285766A1
公开(公告)日：2024-08-29
申请号：US18635538
申请日：2024-04-15
发明人： Alyssa M. Larson , Kevin Love , Alisha K. Weight , Alan Crane , Robert S. Langer , Alexander M. Klibanov
IPC分类号： A61K47/06 , A61K9/00 , A61K9/19 , A61K38/00 , A61K39/395 , A61K47/20 , A61K47/22 , A61K47/24 , C07K16/22 , C07K16/24 , C07K16/28 , C07K16/32
CPC分类号： A61K47/06 , A61K9/0019 , A61K9/19 , A61K39/3955 , A61K47/20 , A61K47/22 , A61K47/24 , C07K16/22 , C07K16/241 , C07K16/2839 , C07K16/2863 , C07K16/2887 , C07K16/32 , A61K38/00
摘要： Concentrated, low-viscosity, low-volume liquid pharmaceutical formulations of proteins have been developed. Such formulations can be rapidly and conveniently administered by subcutaneous or intramuscular injection, rather than by lengthy intravenous infusion. These formulations include low-molecular-weight and/or high-molecular-weight proteins, such as mAbs, and viscosity-reducing ionic liquids.
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