公开(公告)号：US09670213B2

公开(公告)日：2017-06-06

申请号：US14400508

申请日：2013-04-02

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Honglin Li ,  Yufang Xu ,  Zhenjiang Zhao ,  Xiaofeng Liu ,  Wei Zhou ,  Fang Bai ,  Mengzhu Xue ,  Lei Zhang ,  Youli Zhang

IPC分类号： C07D401/12 ,  C07D475/04 ,  C07D487/02 ,  C07D475/00 ,  C07D239/50

CPC分类号： C07D475/00 ,  C07D239/50

摘要： Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the following formula I, a pharmaceutical composition containing the compound of the formula I, and use of compound in preparing medicine for treating diseases mediated by EGFR, BLK, or FLT3 or inhibiting EGFR, BLK, and FLT3.

公开(公告)号：US20150126508A1

公开(公告)日：2015-05-07

申请号：US14400508

申请日：2013-04-02

申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Honglin Li ,  Yufang Xu ,  Zhenjiang Zhao ,  Xiaofeng Liu ,  Wei Zhou ,  Fang Bai ,  Mengzhu Xue ,  Lei Zhang ,  Youli Zhang

IPC分类号： C07D475/00

CPC分类号： C07D475/00 ,  C07D239/50

摘要： Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the following formula I, a pharmaceutical composition containing the compound of the formula I, and use of compound in preparing medicine for treating diseases mediated by EGFR, BLK, or FLT3 or inhibiting EGFR, BLK, and FLT3.

摘要翻译： 提供用作EGFR，BLK和FLT3抑制剂的蝶啶酮衍生物及其应用。 具体地，提供下式I的化合物，含有式I化合物的药物组合物，以及化合物在制备用于治疗由EGFR，BLK或FLT3介导的疾病或抑制EGFR，BLK和FLT3的疾病的药物中的用途。