公开(公告)号：US11306095B2

公开(公告)日：2022-04-19

申请号：US15577518

申请日：2016-05-30

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Honglin Li ,  Yufang Xu ,  Zhenjiang Zhao ,  Wei Zhou ,  Yuqiong Xu ,  Deheng Sun ,  Xia Wang ,  Zhuo Chen

IPC: C07D487/04 ,  A61P35/00 ,  A61P35/02 ,  A61K31/519 ,  C07D475/00

Abstract: The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.