公开(公告)号：US11051934B2

公开(公告)日：2021-07-06

申请号：US16286436

申请日：2019-02-26

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  Juliet Laura Schwartz ,  Wendy Vo Pham ,  Hieu Minh Luong ,  Julio Cesar Sanchez ,  Matthew A. Peterson ,  J. Brent Ratz ,  Lisong Ai

IPC: A61F2/24 ,  A61F2/95

Abstract: A mitral valve prosthesis includes an hourglass shaped inner frame and a bulbous outer frame. A valve body having a plurality of leaflets is positioned within an interior region of the inner frame. The leaflets are shaped to substantially conform to an interior surface of the inner frame when the leaflets are in an open position. As a result, the gap between the leaflets and the inner frame is decreased, thereby reducing the likelihood of thrombus formation. Ventricular anchors are preferably provided along a distal end of the inner frame. The anchors extend proximally for placement behind native mitral valve leaflets. A fabric skirt may extend along an inner or outer surface of the outer frame. In preferred embodiments, the fabric skirt extends distally beyond a distal end of the outer frame and is adapted for forming a seal along the mitral valve annulus.

公开(公告)号：US20210290378A1

公开(公告)日：2021-09-23

申请号：US17343554

申请日：2021-06-09

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  Juliet Laura Schwartz ,  Wendy Vo Pham ,  Hieu Minh Luong ,  Julio Cesar Sanchez ,  Matthew A. Peterson ,  J. Brent Ratz ,  Lisong Ai

IPC: A61F2/24

Abstract: Disclosed herein are embodiments of an expandable replacement heart valve prosthesis. The expandable replacement heart valve prosthesis can include a number of different features, such as an hourglass (or generally hourglass) shape in the fully expanded position, anchor stiffening features, and improved retraction/retention configurations. For example, certain struts on the prosthesis can have different thicknesses/widths than other struts to improve compressibility.

公开(公告)号：US20190262129A1

公开(公告)日：2019-08-29

申请号：US16286436

申请日：2019-02-26

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  Juliet Laura Schwartz ,  Wendy Vo Pham ,  Hieu Minh Luong ,  Julio Cesar Sanchez ,  Matthew A. Peterson ,  J. Brent Ratz ,  Lisong Ai

IPC: A61F2/24

Abstract: A mitral valve prosthesis includes an hourglass shaped inner frame and a bulbous outer frame. A valve body having a plurality of leaflets is positioned within an interior region of the inner frame. The leaflets are shaped to substantially conform to an interior surface of the inner frame when the leaflets are in an open position. As a result, the gap between the leaflets and the inner frame is decreased, thereby reducing the likelihood of thrombus formation. Ventricular anchors are preferably provided along a distal end of the inner frame. The anchors extend proximally for placement behind native mitral valve leaflets. A fabric skirt may extend along an inner or outer surface of the outer frame. In preferred embodiments, the fabric skirt extends distally beyond a distal end of the outer frame and is adapted for forming a seal along the mitral valve annulus.

公开(公告)号：US20250057646A1

公开(公告)日：2025-02-20

申请号：US18934905

申请日：2024-11-01

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Harvey H. Chen ,  Son V. Nguyen ,  Devin D. Nguyen ,  Diana Marie Edwards ,  August R. Yambao ,  Jyoti B. Rao ,  Alyssa E. Kornswiet ,  Lisong Ai ,  Stephen W. Tang ,  Edward Romero ,  Kevin K. Dang ,  Meena Francis ,  Louis A. Campbell ,  Grace Myong Kim

IPC: A61F2/24

Abstract: A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.

公开(公告)号：US12138153B2

公开(公告)日：2024-11-12

申请号：US17389771

申请日：2021-07-30

Applicant: Edwards Lifesciences Corporation

Inventor： Harvey H. Chen ,  Son V. Nguyen ,  Devin D. Nguyen ,  Diana Marie Edwards ,  August R. Yambao ,  Jyoti B. Rao ,  Alyssa E. Kornswiet ,  Lisong Ai ,  Stephen W. Tang ,  Edward Romero ,  Kevin K. Dang ,  Meena Francis ,  Louis A. Campbell ,  Grace Myong Kim

IPC: A61F2/24

Abstract: A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.

公开(公告)号：US20220006850A1

公开(公告)日：2022-01-06

申请号：US17387121

申请日：2021-07-28

Applicant: Edwards Lifesciences Corporation

Inventor： Alexander H. Cooper ,  Juliet Laura Schwartz ,  Wendy Vo Pham ,  Hieu Minh Luong ,  Julio Cesar Sanchez ,  Matthew A. Peterson ,  J. Brent Ratz ,  Lisong Ai

IPC: H04L29/06 ,  G06K9/00 ,  G10L25/60 ,  H04L12/26 ,  G06N20/00 ,  H04L12/24 ,  G10L25/57

Abstract: A method for replacing a native heart valve includes advancing a delivery catheter having a valve prosthesis disposed along a distal end portion thereof, wherein the valve includes an inner frame having an hourglass shape and an outer sealing frame connected to and surrounding the inner frame. A valve body is mounted within the inner frame and includes a plurality of leaflets. The leaflets have longitudinal curvatures when in an open position, wherein the curvatures are shaped for conforming to the curved interior surface of the inner frame. This combination of features reduces the possibility of blood stagnating between the leaflets and inner frame, which reduces the possibility of thrombus formation.

公开(公告)号：US20210353408A1

公开(公告)日：2021-11-18

申请号：US17389771

申请日：2021-07-30

Applicant: Edwards Lifesciences Corporation

Inventor： Harvey H. Chen ,  Son V. Nguyen ,  Devin D. Nguyen ,  Diana Marie George ,  August R. Yambao ,  Jyoti B. Rao ,  Alyssa E. Kornswiet ,  Lisong Ai ,  Stephen W. Tang ,  Edward Romero ,  Kevin K. Dang ,  Meena Francis ,  Louis A. Campbell ,  Grace Myong Kim

IPC: A61F2/24

Abstract: A hybrid heart valve prosthesis that can be quickly and easily implanted during a surgical procedure is provided. The hybrid heart valve includes a substantially non-expandable, non-compressible prosthetic valve member having a peripheral sealing ring and an expandable stent frame projecting from an inflow end, thereby enabling attachment to the annulus without sutures. The stent frame may be plastically-expandable and may have a thin fabric layer covering its entirety as well as secondary sealing structures around its periphery to prevent paravalvular leaking. Other sealing solutions include interactive steps at the time of valve implant to establish seals around the stent and especially between the stent and the sealing ring of the valve member.