公开(公告)号：US12109564B2

公开(公告)日：2024-10-08

申请号：US16972283

申请日：2019-06-05

申请人： ELTEK S.p.A.

发明人： Marco Pizzi ,  Giovanni Melioli ,  Valentina Gallo ,  Massimo Zanin

IPC分类号： B01L3/00 ,  C12Q1/18

CPC分类号： B01L3/502753 ,  C12Q1/18 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0806 ,  B01L2300/161

摘要： A microfluidic device for concentrating particles contained in a fluid sample (FS) comprises a substrate (11) configured for being set in rotation about a centre of rotation (5a), the substrate (11) having a surface (11b) defined in which is at least one microfluidic arrangement (12) that extends substantially according to a plane identified by the substrate (11). The at least one microfluidic arrangement (12) comprises at least one microchannel (13) having a first end (13a) and a second end (13b), wherein: —the at least one microchannel (13) comprises, in a region thereof intermediate between its first end (13a) and its second end (13a), at least one accumulation area (15) that is at a first distance (R1) in a radial direction (R) from the centre of rotation (5a) of the substrate (11); —the first end (13a) and the second end (13b) of the at least one microchannel (13) are at second distances (R2) in a radial direction (R) from the centre of rotation (5a) of the substrate (11); and —the first distance (R1) in a radial direction (R) is greater than the second distances (R2) in a radial direction (R), in such a way that particles (P) possibly contained in a volume of fluid of the fluid sample (FS) that penetrates into the at least one microchannel (13) tend to concentrate in the at least one accumulation area (15) as a result of the centrifugal force caused by a rotation of the substrate (11) about the centre of rotation (5a).