公开(公告)号：US20170319841A1

公开(公告)日：2017-11-09

申请号：US15150112

申请日：2016-05-09

Applicant: Elwha LLC

Inventor： JESSE R. CHEATHAM, III ,  JOEL CHERKIS ,  PAUL H. DIETZ ,  TOM DRISCOLL ,  WILLIAM GATES ,  RODERICK A. HYDE ,  MURIEL Y. ISHIKAWA ,  NEIL JORDAN ,  JORDIN T. KARE ,  ERIC C. LEUTHARDT ,  NATHAN P. MYHRVOLD ,  PATRICK NEILL ,  TONY S. PAN ,  ROBERT C. PETROSKI ,  DAVID R. SMITH ,  ELIZABETH A. SWEENEY ,  DESNY S. TAN ,  CLARENCE T. TEGREENE ,  DAVID LAWRENCE TENNENHOUSE ,  YAROSLAV A. URZHUMOV ,  GARY WACHOWICZ ,  LOWELL L. WOOD, JR. ,  VICTORIA Y.H. WOOD

IPC: A61M37/00 ,  A61M35/00

CPC classification number: A61M37/0092 ,  A61M2037/0007

Abstract: Described embodiments include a system, method, and apparatus. A system includes a medicament-eluting device configured to be positioned at a location on a skin of a mammal. The system includes an ultrasonic wave transmitter configured to emit ultrasonic shear waves directable at the location. The ultrasonic shear waves have a frequency or amplitude selected to increase a permeability of the skin of the mammal to a medicament released by the medicament-eluting device. In an embodiment, the system includes a structure carrying the medicament-eluting device and the ultrasonic wave transmitter. In an embodiment, the system includes a cavitation sensor configured to detect a cavitation event in the mammal. In an embodiment, the system includes a cavitation controller configured to limit a power of the ultrasonic shear waves directed at the location to a level below a cavitation threshold of the mammal.

公开(公告)号：US20170319840A1

公开(公告)日：2017-11-09

申请号：US15150086

申请日：2016-05-09

Applicant: Elwha LLC

Inventor： JESSE R. CHEATHAM, III ,  JOEL CHERKIS ,  PAUL H. DIETZ ,  TOM DRISCOLL ,  WILLIAM GATES ,  RODERICK A. HYDE ,  MURIEL Y. ISHIKAWA ,  NEIL JORDAN ,  JORDIN T. KARE ,  ERIC C. LEUTHARDT ,  NATHAN P. MYHRVOLD ,  PATRICK NEILL ,  TONY S. PAN ,  ROBERT C. PETROSKI ,  DAVID R. SMITH ,  ELIZABETH A. SWEENEY ,  DESNY S. TAN ,  CLARENCE T. TEGREENE ,  DAVID LAWRENCE TENNENHOUSE ,  YAROSLAV A. URZHUMOV ,  GARY WACHOWICZ ,  LOWELL L. WOOD, JR. ,  VICTORIA Y.H. WOOD

IPC: A61M37/00 ,  A61F13/15 ,  A61M1/00

CPC classification number: A61M37/0092 ,  A61B2010/008 ,  A61M1/0023 ,  A61M2037/0007 ,  A61M2037/0061 ,  A61M2205/3303 ,  A61M2205/3375

Abstract: Described embodiments include a system, method, and apparatus. A system includes an extracellular-fluid collection device configured to be positioned at a location on a skin of a mammal. In an embodiment, the mammal includes a live human. The system includes an ultrasonic wave transmitter configured to emit ultrasonic shear waves directable at the location. The ultrasonic shear waves have a frequency or amplitude selected to increase a permeability of the skin of the mammal to an extracellular-fluid. In an embodiment, the system includes a sensor configured to determine a rate or amount of extracellular-fluid collected by the extracellular-fluid collection device. In an embodiment, the system includes a fluid collection controller configured to regulate a parameter of ultrasonic shear waves transmitted by the ultrasonic wave transmitter in response to a determined rate or amount of fluid collected by the extracellular-fluid collection device.

公开(公告)号：US20160013009A1

公开(公告)日：2016-01-14

申请号：US14863098

申请日：2015-09-23

Applicant: ELWHA LLC

Inventor： JESSE R. CHEATHAM, III ,  PHILIP ANDREW ECKHOFF ,  WILLIAM GATES ,  MURIEL Y. ISHIKAWA ,  JORDIN T. KARE ,  NATHAN P. MYHRVOLD ,  TONY S. PAN ,  ROBERT C. PETROSKI ,  CLARENCE T. TEGREENE ,  DAVID B. TUCKERMAN ,  CHARLES WHITMER ,  LOWELL L. WOOD, JR. ,  VICTORIA Y.H. WOOD ,  RODERICK A. HYDE

IPC: H01J19/38 ,  H01J45/00 ,  H01J21/06

CPC classification number: H01J19/38 ,  H01J19/78 ,  H01J19/80 ,  H01J21/06 ,  H01J29/02 ,  H01J29/481 ,  H01J45/00

Abstract: A field emission device is configured as a heat engine, wherein the configuration of the heat engine is variable.