公开(公告)号：US12281297B2

公开(公告)日：2025-04-22

申请号：US17086249

申请日：2020-10-30

Applicant: EMD Millipore Corporation

Inventor： Roderick J. Ray ,  Adam S. Carroll ,  Brandon J. Downey ,  Lisa J. Graham

IPC: C12M1/36 ,  C12M1/00 ,  C12M1/12 ,  C12M1/26 ,  C12M1/34 ,  C12Q3/00 ,  G01N33/48

Abstract: The present disclosure is directed to systems and methods for sampling and/or controlling the productivity of a bioreactor. The system and methods can include a vessel capable of providing an environment suitable for containing whole broth that can produce the bioproduct, wherein the whole broth contains media and at least one undissolved species, an automated sampling system, a first analytical instrument, and a control system.