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公开(公告)号：US20210254248A1
公开(公告)日：2021-08-19
申请号：US17167371
申请日：2021-02-04
Applicant: EMD Millipore Corporation
Inventor： Nitin Satav , Martin Cuddy, JR. , Xiaozhu Zhou , Saptarshi Chattopadhyay , William Trinh , Onur Y. Kas , David Nhiem
Abstract: Provided herein are sterilizable porous filtration media and methods of making and using the same.
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公开(公告)号：US10119897B2
公开(公告)日：2018-11-06
申请号：US15057641
申请日：2016-03-01
Applicant: EMD Millipore Corporation
Inventor： Salvatore Giglia , David Nhiem , Gabriel Tkacik
Abstract: A method of aerosol integrity testing of filters, capable of detecting single defects that are less than 20 μm in diameter, and even as small as 2 μm in diameter, in liquid sterilizing grade filters such as filter cartridges. The method challenges the filter in a dry state with a particle stream of aerosol particles of the appropriate size and in the appropriate concentration, such that at least one or more of the particles in the stream will penetrate a defective region or regions within the membrane but will not penetrate in the integral region of the membrane. Wetting of the filter is not required.
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公开(公告)号：US20160299048A1
公开(公告)日：2016-10-13
申请号：US15057641
申请日：2016-03-01
Applicant: EMD Millipore Corporation
Inventor： Salvatore Giglia , David Nhiem , Gabriel Tkacik
IPC: G01N15/08
CPC classification number: G01N15/088 , B01D65/102 , B01D2273/18 , G01M3/20 , G01N15/0826 , G01N2015/084 , G01N2015/0846
Abstract: A method of aerosol integrity testing of filters, capable of detecting single defects that are less than 20 μm in diameter, and even as small as 2 μm in diameter, in liquid sterilizing grade filters such as filter cartridges. The method challenges the filter in a dry state with a particle stream of aerosol particles of the appropriate size and in the appropriate concentration, such that at least one or more of the particles in the stream will penetrate a defective region or regions within the membrane but will not penetrate in the integral region of the membrane. Wetting of the filter is not required.
Abstract translation: 一种过滤器的气溶胶完整性测试方法，能够检测液体杀菌级过滤器（如过滤器滤芯）中直径小于20μm，直径小至2μm的单一缺陷。 该方法在干燥状态下用适当尺寸和适当浓度的气溶胶颗粒的颗粒流挑战过滤器，使得流中的至少一种或多种颗粒将渗透膜内的缺陷区域或区域，但 不会渗入膜的整体区域。 不需要过滤器的润湿。
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公开(公告)号：US11192070B2
公开(公告)日：2021-12-07
申请号：US16862137
申请日：2020-04-29
Applicant: EMD Millipore Corporation
Inventor： Salvatore Giglia , David Nhiem
Abstract: A method of integrity testing a porous material is disclosed, providing a porous material suitable for filtration to be tested, said porous material having a first surface and a second surface; wetting said porous material with a wetting liquid; providing a gas stream comprising at least first and second gases humidified with said wetting liquid below the saturation vapor pressure of said wetting liquid and wherein said humidified gas stream has a humidity of 50-99%; introducing said gas stream to said first surface of said porous material; causing said first and second gases to flow through said porous material; measuring the concentration of at least one of said first and second gases in the permeate stream exiting said second surface of said porous material; and comparing the measured concentration to a predetermined concentration.
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Patent Agency Ranking
公开(公告)号：US20180257039A1
公开(公告)日：2018-09-13
申请号：US15770893
申请日：2016-09-12
Applicant: EMD Millipore Corporation
Inventor： Salvatore Giglia , David Nhiem
Abstract: A method of integrity testing porous materials that is non-destructive to the material being tested. The method includes humidifying the inlet gas stream to minimize or prevent the porous material from drying out. The inlet gas stream includes at least two gases, wherein one of the gases has a different permeability in liquid than the other, such as oxygen and nitrogen. The permeate gas stream may be subjected to a driving force such as reduced pressure to increase the flow of gases and reduce test time. Multiple porous materials can be integrity tested at the same time, such as by manifolding a plurality of them together. The integrity test is capable of detecting the presence of oversized pores or defects that can compromise the retention capability of the porous material.
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公开(公告)号：US12059644B2
公开(公告)日：2024-08-13
申请号：US15301781
申请日：2015-06-23
Applicant: EMD Millipore Corporation
Inventor： Sal Giglia , David Nhiem , Sherry Ashby Leon , Gabriel Tkacik
IPC: B01D39/16
CPC classification number: B01D39/1623 , B01D2239/025 , B01D2239/0631 , B01D2239/065
Abstract: A fluid filtration device containing a composite filter media having a coarse porous polymeric nonwoven interlayer located between first and second polymeric fiber containing filter mats. The fiber diameters of the fibers in the first and second filter mats are different from each other, and each filter mat has a different pore size rating. The first and second polymeric fibers in the filter mats can be electrospun nanofibers. The interlayer has a coarser pore size when compared to the either the first or second filter mats, such that the resulting composite media has an increased dirt holding capacity compared to filter layers that are layered directly over each other without the presence of a coarse interlayer therebetween.
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公开(公告)号：US20200254392A1
公开(公告)日：2020-08-13
申请号：US16862137
申请日：2020-04-29
Applicant: EMD Millipore Corporation
Inventor： Salvatore Giglia , David Nhiem
Abstract: A method of integrity testing a porous material is disclosed, providing a porous material suitable for filtration to be tested, said porous material having a first surface and a second surface; wetting said porous material with a wetting liquid; providing a gas stream comprising at least first and second gases humidified with said wetting liquid below the saturation vapor pressure of said wetting liquid and wherein said humidified gas stream has a humidity of 50-99%; introducing said gas stream to said first surface of said porous material; causing said first and second gases to flow through said porous material; measuring the concentration of at least one of said first and second gases in the permeate stream exiting said second surface of said porous material; and comparing the measured concentration to a predetermined concentration.
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公开(公告)号：US10702832B2
公开(公告)日：2020-07-07
申请号：US15770893
申请日：2016-09-12
Applicant: EMD Millipore Corporation
Inventor： Salvatore Giglia , David Nhiem
Abstract: A method of integrity testing porous materials that is non-destructive to the material being tested. The method includes humidifying the inlet gas stream to minimize or prevent the porous material from drying out. The inlet gas stream includes at least two gases, wherein one of the gases has a different permeability in liquid than the other, such as oxygen and nitrogen. The permeate gas stream may be subjected to a driving force such as reduced pressure to increase the flow of gases and reduce test time. Multiple porous materials can be integrity tested at the same time, such as by manifolding a plurality of them together. The integrity test is capable of detecting the presence of oversized pores or defects that can compromise the retention capability of the porous material.
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公开(公告)号：US10151679B2
公开(公告)日：2018-12-11
申请号：US15057641
申请日：2016-03-01
Applicant: EMD Millipore Corporation
Inventor： Salvatore Giglia , David Nhiem , Gabriel Tkacik
Abstract: A method of aerosol integrity testing of filters, capable of detecting single defects that are less than 20 μm in diameter, and even as small as 2 μm in diameter, in liquid sterilizing grade filters such as filter cartridges. The method challenges the filter in a dry state with a particle stream of aerosol particles of the appropriate size and in the appropriate concentration, such that at least one or more of the particles in the stream will penetrate a defective region or regions within the membrane but will not penetrate in the integral region of the membrane. Wetting of the filter is not required.
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