公开(公告)号：US11674184B2

公开(公告)日：2023-06-13

申请号：US16766297

申请日：2018-11-21

申请人： ENHANCEDBIO INC.

发明人： Eun Kyung Choi ,  Seong-Yun Jeong ,  Si Yeol Song ,  Yun-Yong Park ,  Seok Soon Park ,  Eun Jin Ju ,  Eun Jung Ko

IPC分类号： A61K38/55 ,  A61K31/7105 ,  A61P35/00 ,  C12N15/113 ,  C12Q1/6886 ,  A61K38/00

CPC分类号： C12Q1/6886 ,  A61K31/7105 ,  A61K38/005 ,  A61K38/55 ,  A61P35/00 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y207/04002

摘要： The present invention relates to a biomarker composition for diagnosing radiation-resistant cancer comprising PMVK as an active ingredient and a method of diagnosing radiation-resistant cancer using the same, and when the PMVK is knocked down, it is confirmed that the survival rate of cancer cells decreases during radiation treatment, and based on this, the possibility as a factor related to radiation therapy resistance to cancer was suggested, and the PMVK can be used as a new target to enhance the effect of radiation therapy on human cancer cells.