专利检索 ap:("EPIZYME, INC.") AND inv:"Carl Eric SCHWARTZ" 第 1 页

1.

发明申请
Isoxazole Carboxamides as Irreversible SMYD Inhibitors 审中-公开

公开(公告)号：US20180230110A1

公开(公告)日：2018-08-16

申请号：US15510589

申请日：2015-09-09

申请人： EPIZYME, INC.

发明人： Richard CHESWORTH , Megan Alene Cloonan FOLEY , Kevin Wayne KUNTZ , Lorna Helen MITCHELL , Russell C. PETTER , Carl Eric SCHWARTZ

IPC分类号： C07D261/18 , A61P35/00 , A61P35/02 , A61P35/04 , C07D413/12

CPC分类号： C07D261/18 , A61P35/00 , A61P35/02 , A61P35/04 , C07D413/12

摘要： The present disclosure provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2a, R2b, R3a, R3b, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.