公开(公告)号：US12082581B2

公开(公告)日：2024-09-10

申请号：US17623129

申请日：2020-06-26

Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED

Inventor： Hiroto Tamashima

IPC: A01N37/38 ,  A01N37/36 ,  A01N37/50 ,  A01N43/08 ,  A01N43/10 ,  A01N43/20 ,  A01N43/40 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  A01N47/10 ,  A01N47/16 ,  A01N47/22 ,  A01N55/00 ,  A01N55/08 ,  A61P1/00 ,  A61P3/00 ,  A61P7/00 ,  C07C69/712 ,  C07C69/734 ,  C07C69/736 ,  C07C251/40 ,  C07C255/54 ,  C07C271/40 ,  C07C271/44 ,  C07C271/56 ,  C07C271/58 ,  C07C307/02 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C333/04 ,  C07D207/08 ,  C07D213/30 ,  C07D213/61 ,  C07D241/16 ,  C07D261/18 ,  C07D277/24 ,  C07D295/088 ,  C07D295/205 ,  C07D303/23 ,  C07D307/12 ,  C07D307/42 ,  C07D333/16 ,  C07F7/08

CPC classification number: A01N37/38 ,  A01N37/50 ,  A01N43/08 ,  A01N43/10 ,  A01N43/20 ,  A01N43/40 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  A01N55/00 ,  C07C69/736 ,  C07C251/40 ,  C07D213/61 ,  C07D241/16 ,  C07D261/18 ,  C07D277/24 ,  C07D295/088 ,  C07D303/23 ,  C07D307/12 ,  C07D333/16 ,  C07F7/081

Abstract: The present invention provides a compound represented by formula (I) [wherein L represents an oxygen atom or CH2, E represents a C2-C10 chain hydrocarbon group or the like, R1 represents a C1-C3 chain hydrocarbon group or the like, R2 represents a C1-C3 chain hydrocarbon group or the like, and n is 0, 1, 2 or 3.] or its N oxide or agriculturally acceptable salt, which is a compound that have excellent pests controlling effects.

公开(公告)号：US20240279174A1

公开(公告)日：2024-08-22

申请号：US18626187

申请日：2024-04-03

Applicant: Duke University

Inventor： Pei Zhou ,  Jiyong Hong

IPC: C07D209/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/706 ,  C07D213/72 ,  C07D213/89 ,  C07D249/04 ,  C07D261/18 ,  C07D295/26 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07H11/04

CPC classification number: C07D209/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/706 ,  C07D213/72 ,  C07D213/89 ,  C07D249/04 ,  C07D261/18 ,  C07D295/26 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07H11/04

Abstract: Disclosed herein are novel antibiotic compositions and methods of making and using the same. The antibiotic compositions may comprise LPXH-targeting compounds.

公开(公告)号：US12060333B2

公开(公告)日：2024-08-13

申请号：US17445989

申请日：2021-08-26

Applicant: Hoffmann-La Roche Inc.

Inventor： Chungen Liang ,  Hongying Yun ,  Weixing Zhang ,  Kun Miao ,  Jianguo Chen ,  Yao Wu

IPC: C07D241/24 ,  C07C243/34 ,  C07C311/35 ,  C07D207/26 ,  C07D209/42 ,  C07D211/76 ,  C07D231/12 ,  C07D233/64 ,  C07D235/24 ,  C07D261/18 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12

CPC classification number: C07D241/24 ,  C07C243/34 ,  C07C311/35 ,  C07D207/26 ,  C07D209/42 ,  C07D211/76 ,  C07D231/12 ,  C07D233/64 ,  C07D235/24 ,  C07D261/18 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12

Abstract: The present invention relates to compounds of formula (I),




wherein R1-R5 and L are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

公开(公告)号：US11919839B2

公开(公告)日：2024-03-05

申请号：US17238529

申请日：2021-04-23

Applicant: Valo Health, Inc.

Inventor： Kenneth W. Bair ,  Nicholas Barczak ,  Bingsong Han ,  David R. Lancia, Jr. ,  Cuixian Liu ,  Matthew W. Martin ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Xiaozhang Zheng

IPC: C07C259/06 ,  A61K31/185 ,  A61K31/277 ,  A61K31/397 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/417 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/495 ,  A61K31/5377 ,  C07D207/10 ,  C07D207/267 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D209/46 ,  C07D211/16 ,  C07D211/58 ,  C07D213/56 ,  C07D213/65 ,  C07D213/75 ,  C07D213/81 ,  C07D215/12 ,  C07D221/20 ,  C07D231/14 ,  C07D231/18 ,  C07D233/36 ,  C07D233/38 ,  C07D233/68 ,  C07D235/14 ,  C07D235/30 ,  C07D239/20 ,  C07D239/22 ,  C07D241/08 ,  C07D241/12 ,  C07D249/18 ,  C07D257/04 ,  C07D261/18 ,  C07D277/56 ,  C07D295/155 ,  C07D295/192 ,  C07D307/68 ,  C07D317/68 ,  C07D333/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/10 ,  C07D493/08 ,  C07D495/10 ,  C07D498/04 ,  C07D513/10

CPC classification number: C07C259/06 ,  A61K31/185 ,  A61K31/277 ,  A61K31/397 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/417 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/495 ,  A61K31/5377 ,  C07D207/10 ,  C07D207/267 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D209/46 ,  C07D211/16 ,  C07D211/58 ,  C07D213/56 ,  C07D213/65 ,  C07D213/75 ,  C07D213/81 ,  C07D215/12 ,  C07D221/20 ,  C07D231/14 ,  C07D231/18 ,  C07D233/36 ,  C07D233/38 ,  C07D233/68 ,  C07D235/14 ,  C07D235/30 ,  C07D239/20 ,  C07D239/22 ,  C07D241/08 ,  C07D241/12 ,  C07D249/18 ,  C07D257/04 ,  C07D261/18 ,  C07D277/56 ,  C07D295/155 ,  C07D295/192 ,  C07D307/68 ,  C07D317/68 ,  C07D333/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/10 ,  C07D493/08 ,  C07D495/10 ,  C07D498/04 ,  C07D513/10 ,  Y02A50/30

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

公开(公告)号：US20240067600A1

公开(公告)日：2024-02-29

申请号：US18122605

申请日：2023-03-16

Applicant: UNIVERSITY OF KANSAS ,  Oregon Health & Science University

Inventor： Sudeshna ROY ,  Paolo BERNARDI ,  Michael FORTE ,  Frank SCHOENEN ,  Justina SILEIKYTE

IPC: C07C235/42 ,  A61K31/415 ,  A61K31/42 ,  A61P21/00 ,  A61P25/00 ,  C07C235/38 ,  C07C235/56 ,  C07D203/04 ,  C07D211/14 ,  C07D231/14 ,  C07D261/18 ,  C07D295/135 ,  C07D295/185 ,  C07D413/12

CPC classification number: C07C235/42 ,  A61K31/415 ,  A61K31/42 ,  A61P21/00 ,  A61P25/00 ,  C07C235/38 ,  C07C235/56 ,  C07D203/04 ,  C07D211/14 ,  C07D231/14 ,  C07D261/18 ,  C07D295/135 ,  C07D295/185 ,  C07D413/12

Abstract: The present technology relates to compounds of any one of Formula I, II, IIa, III, IV, and/or V as described herein and their tautomers and/or pharmaceutically acceptable salts, compositions, and methods of uses thereof.

公开(公告)号：US11760742B2

公开(公告)日：2023-09-19

申请号：US17208474

申请日：2021-03-22

Applicant: MITSUI CHEMICALS, INC.

Inventor： Kei Yoshida ,  Takeo Wakita ,  Hiroyuki Katsuta ,  Akiyoshi Kai ,  Yutaka Chiba ,  Kiyoshi Takahashi ,  Hiroko Kato ,  Nobuyuki Kawahara ,  Michikazu Nomura ,  Hidenori Daido ,  Junji Maki ,  Shinichi Banba

IPC: C07C237/42 ,  C07D333/38 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/78 ,  A01N43/80 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/30 ,  C07D241/24 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D309/08 ,  C07D309/28 ,  C07D317/62 ,  C07D333/68 ,  A01N43/40 ,  A01N37/22 ,  A01N43/60 ,  C07C237/48 ,  C07D207/34 ,  C07D239/28 ,  C07D261/18 ,  C07D307/85 ,  C07D317/46

CPC classification number: C07D333/38 ,  A01N37/22 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  C07C237/42 ,  C07C237/48 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/34 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/28 ,  C07D239/30 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D309/08 ,  C07D309/28 ,  C07D317/46 ,  C07D317/62 ,  C07D333/68

Abstract: A compound represented by Formula (1):




The compound can be used as insecticides.

公开(公告)号：US20180221431A1

公开(公告)日：2018-08-09

申请号：US15504951

申请日：2015-08-12

Applicant: CORNELL UNIVERSITY

Inventor： Gang LIN ,  Carl NATHAN ,  Pradeep K. SINGH

IPC: A61K38/05 ,  C07K5/06 ,  A61K31/42 ,  A61K38/02 ,  A61K31/165

CPC classification number: A61K38/05 ,  A61K31/165 ,  A61K31/42 ,  A61K38/02 ,  C07C237/06 ,  C07C237/12 ,  C07C237/22 ,  C07C271/22 ,  C07C311/14 ,  C07C311/19 ,  C07C2601/02 ,  C07D209/18 ,  C07D261/18 ,  C07K5/06

Abstract: The compounds of the present invention are represented by the following compounds having Formula I, where the substituents R1, R4, L, M, X, Y, and s are as defined herein. The compounds of the present invention are also represented by the following compounds having Formula (Ia), Formula (Ib), or Formula (Ic), where the substituents R1-R4, RX, RY, X, Y, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.

公开(公告)号：US10017480B2

公开(公告)日：2018-07-10

申请号：US15119034

申请日：2015-02-10

Applicant: UNIVERSITÂ DEGLI STUDI DI GENOVA ,  THE TRUSTEES OF COLUMBIA UNIVERSITY ,  MAASTRICHT UNIVERSITY

Inventor： Olga Bruno ,  Chiara Brullo ,  Alessia Romussi ,  Ernesto Fedele ,  Roberta Ricciarelli ,  Ottavio Arancio ,  Jos Prickaerts

IPC: C07D207/34 ,  C07D207/337 ,  C07D231/12 ,  C07D261/04 ,  C07D261/08 ,  C07D261/18 ,  C07D401/06 ,  C07D413/06 ,  C07D403/06

CPC classification number: C07D261/04 ,  C07D207/337 ,  C07D207/34 ,  C07D231/12 ,  C07D261/08 ,  C07D261/18 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06

Abstract: Compounds of formula (I), wherein Z=cyclopentyl. cyclopropylmethyl, —CH3; R′═—CH3, CHF2, X=formula (II) (III) (IV) (V) Y=—CO; —C═O(CH2), —CH(OH)—CH2, —CH2—C═O, —CH2—CH2—C═O; —CH2—CH(OH)—CH2, —CH2—CH(OCOR1)—CH2 NR2═ —N(CH2—CH2OH)2, formula (VI) (VII) (VIII) (IX) (X) (XI) R1=optionally substituted C1-C8 alkyl, optionally substituted aryl; optionally substituted aralkyl, preferably C1-C3 alkyl, more preferably CH3; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof; these compounds have a PDE4D inhibiting activity and can be used as a medicament for treating dementia, in particular Alzheimer disease, and for improving memory.

公开(公告)号：US20180105503A1

公开(公告)日：2018-04-19

申请号：US15689168

申请日：2017-08-29

Applicant: THERAVANCE BIOPHARMA R&D IP, LLC

Inventor： Melissa Fleury ,  Roland Gendron ,  Adam D. Hughes ,  Jane Schmidt

IPC: C07D261/18 ,  A61K45/06 ,  A61K31/42

CPC classification number: C07D261/18 ,  A01N47/16 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4355 ,  A61K31/437 ,  A61K45/06 ,  A61K47/55 ,  A61K47/6895 ,  C07D213/81 ,  C07D237/04 ,  C07D237/24 ,  C07D239/28 ,  C07D241/24 ,  C07D249/04 ,  C07D249/10 ,  C07D249/18 ,  C07D263/34 ,  C07D307/68 ,  C07D333/38 ,  C07D401/06 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C09K15/30

Abstract: In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, X, R4, R5, and R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：US20180099981A1

公开(公告)日：2018-04-12

申请号：US15721470

申请日：2017-09-29

Applicant: Denali Therapeutics Inc.

Inventor： Anthony A. Estrada ,  Jianwen A. Feng ,  Brian Fox ,  Colin Philip Leslie ,  Joseph P. Lyssikatos ,  Alfonso Pozzan ,  Zachary K. Sweeney ,  Javier de Vicente Fidalgo

IPC: C07D513/04 ,  C07D491/048 ,  C07D498/14 ,  C07D498/04 ,  C07D495/04 ,  C07D487/04 ,  C07D261/18 ,  C07D413/14 ,  C07D413/12 ,  C07D403/12 ,  C07D267/14 ,  C07D471/04 ,  C07D417/12

CPC classification number: C07D513/04 ,  C07D261/18 ,  C07D267/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D498/14

Abstract: The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.