公开(公告)号：US20210253665A1

公开(公告)日：2021-08-19

申请号：US17181913

申请日：2021-02-22

申请人： EUREKA THERAPEUTICS, INC.

发明人： Jingwei LU ,  Zhiyuan YANG ,  Cheng LIU ,  Hong LIU ,  Yiyang XU ,  Su YAN ,  Vivien Wai-Fan CHAN ,  Lucas HORAN

IPC分类号： C07K14/725 ,  A61K35/17 ,  C12N15/62 ,  A61K38/00 ,  A61P35/00 ,  A61K39/395 ,  C07K16/28

摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

公开(公告)号：US20190338035A1

公开(公告)日：2019-11-07

申请号：US16477509

申请日：2018-01-11

申请人： EUREKA THERAPEUTICS, INC.

发明人： Vivien Wai-Fan CHAN ,  Hong LIU ,  Yoko NAKANO ,  Yiyang XU

IPC分类号： C07K16/28 ,  G01N33/569 ,  C07K16/46 ,  C07K14/705 ,  C07K14/725 ,  A61K47/68 ,  G01N33/574 ,  A61K35/17

摘要： The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising a histone H3 peptide and an MHC class I protein. Also provided are methods of making and using these constructs.

公开(公告)号：US20220348629A1

公开(公告)日：2022-11-03

申请号：US17716667

申请日：2022-04-08

申请人： EUREKA THERAPEUTICS, INC.

发明人： Jingwei LU ,  Zhiyuan YANG ,  Cheng LIU ,  Hong LIU ,  Yiyang XU ,  Su YAN ,  Vivien Wai-Fan CHAN ,  Lucas HORAN

IPC分类号： C07K14/725 ,  A61K35/17 ,  C12N15/62 ,  A61K38/00 ,  A61P35/00 ,  A61K39/395 ,  C07K16/28

摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

公开(公告)号：US20200087400A1

公开(公告)日：2020-03-19

申请号：US15746367

申请日：2016-07-22

申请人： EUREKA THERAPEUTICS, INC.

发明人： Hong LIU ,  Jingyi XIANG ,  Yiyang XU ,  Vivien Wai-Fan CHAN

IPC分类号： C07K16/28 ,  C07K16/30

摘要： The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising a PSA peptide and an MHC class I protein. Also provided are methods of making and using these constructs.

公开(公告)号：US20190248865A1

公开(公告)日：2019-08-15

申请号：US15769724

申请日：2016-10-21

申请人： EUREKA THERAPEUTICS, INC.

发明人： Jingwei LU ,  Zhiyuan YANG ,  Cheng LIU ,  Hong LIU ,  Yiyang XU ,  Su YAN ,  Vivien Wai-Fan CHAN ,  Lucas HORAN

IPC分类号： C07K14/725 ,  C07K16/28

CPC分类号： C07K14/7051 ,  A61K35/17 ,  A61K38/00 ,  A61K39/39558 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2833 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/33 ,  C07K2319/74 ,  C12N15/62

摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

公开(公告)号：US20200115434A1

公开(公告)日：2020-04-16

申请号：US16667781

申请日：2019-10-29

申请人： EUREKA THERAPEUTICS, INC.

发明人： Jingwei LU ,  Zhiyuan YANG ,  Cheng LIU ,  Hong LIU ,  Yiyang XU ,  Su YAN ,  Vivien Wai-Fan CHAN ,  Lucas HORAN

IPC分类号： C07K14/725 ,  C07K16/28 ,  A61K39/395 ,  A61K38/00 ,  C12N15/62 ,  A61K35/17 ,  A61P35/00

摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

公开(公告)号：US20190022216A1

公开(公告)日：2019-01-24

申请号：US16121475

申请日：2018-09-04

申请人： EUREKA THERAPEUTICS, INC.

发明人： Jingwei LU ,  Zhiyuan YANG ,  Cheng LIU ,  Hong LIU ,  Yiyang XU ,  Su YAN ,  Vivien Wai-Fan CHAN ,  Lucas HORAN

IPC分类号： A61K39/395 ,  A61K35/17 ,  A61K38/00 ,  C07K14/725 ,  C07K16/28 ,  C12N15/62

CPC分类号： C07K14/7051 ,  A61K35/17 ,  A61K38/00 ,  A61K39/39558 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2833 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/33 ,  C07K2319/74 ,  C12N15/62

摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.

公开(公告)号：US20180085457A1

公开(公告)日：2018-03-29

申请号：US15829793

申请日：2017-12-01

申请人： EUREKA THERAPEUTICS, INC.

发明人： Jingwei LU ,  Zhiyuan YANG ,  Cheng LIU ,  Hong LIU ,  Yiyang XU ,  Su YAN ,  Vivien Wai-Fan CHAN ,  Lucas HORAN

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： A61K39/39558 ,  A61K35/17 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/7051 ,  C07K16/2809 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/33 ,  C07K2319/74 ,  C12N15/62

摘要： The present application provides antibody-TCR chimeric constructs comprising an antibody moiety that specifically binds to a target antigen fused to a TCRM capable of recruiting at least one TCR-associated signaling module. Also provided are methods of making and using these constructs.