公开(公告)号：US20190338035A1

公开(公告)日：2019-11-07

申请号：US16477509

申请日：2018-01-11

申请人： EUREKA THERAPEUTICS, INC.

发明人： Vivien Wai-Fan CHAN ,  Hong LIU ,  Yoko NAKANO ,  Yiyang XU

IPC分类号： C07K16/28 ,  G01N33/569 ,  C07K16/46 ,  C07K14/705 ,  C07K14/725 ,  A61K47/68 ,  G01N33/574 ,  A61K35/17

摘要： The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising a histone H3 peptide and an MHC class I protein. Also provided are methods of making and using these constructs.

公开(公告)号：US20210403597A1

公开(公告)日：2021-12-30

申请号：US17292749

申请日：2019-11-14

申请人： Memorial Sloan Kettering Cancer Center ,  Eureka Therapeutics, Inc.

发明人： David SPRIGGS ,  Javier MORALES ,  Yoko NAKANO ,  Hong LIU

IPC分类号： C07K16/30 ,  A61P35/00

摘要： Provided herein are compositions, methods, and uses involving anti-Mucin-16 (MUC16) agents that immunospecifically bind an epitope of Mucin-16 (MUC16). Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer and diseases associated with positive MUC16 expression.

公开(公告)号：US20210107992A1

公开(公告)日：2021-04-15

申请号：US16608377

申请日：2018-04-24

申请人： EUREKA THERAPEUTICS, INC.

发明人： Pengbo ZHANG ,  Yiyang XU ,  Javier MORALES ,  Yoko NAKANO ,  Hong LIU ,  Jingyi XIANG ,  Timothy ACKER

IPC分类号： C07K16/30 ,  C07K14/705 ,  C07K14/725 ,  G01N33/574 ,  C07K16/28 ,  A61P35/00

摘要： The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.