公开(公告)号：US11673957B2

公开(公告)日：2023-06-13

申请号：US15555036

申请日：2016-03-10

申请人： EUREKA THERAPEUTICS, INC. ,  MEMORIAL SLOAN-KETTERING CANCER CENTER

发明人： Cheng Liu ,  Su Yan ,  Pei Wang ,  Nai-Kong Cheung ,  Hongfen Guo ,  Ming Cheng

IPC分类号： C07K16/18 ,  C07K16/28 ,  A61K47/68 ,  C07K16/22 ,  A61K39/00

CPC分类号： C07K16/2857 ,  A61K47/6891 ,  C07K16/22 ,  C07K16/2803 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94

摘要： The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.