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公开(公告)号：US11673957B2
公开(公告)日：2023-06-13
申请号：US15555036
申请日：2016-03-10
发明人： Cheng Liu , Su Yan , Pei Wang , Nai-Kong Cheung , Hongfen Guo , Ming Cheng
CPC分类号： C07K16/2857 , A61K47/6891 , C07K16/22 , C07K16/2803 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/622 , C07K2317/732 , C07K2317/92 , C07K2317/94
摘要： The invention relates to antibodies, and in particular, to antibodies exhibiting specificity for Receptor tyrosine kinase-like Orphan Receptors (ROR), and to uses thereof for example in the treatment of cancer. The invention extends to polynucleotide and polypeptide sequences encoding the antibodies, and therapeutic uses thereof, and to diagnostic kits comprising these molecules. The invention also extends to antibody-drug conjugates and to uses thereof in therapy.
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公开(公告)号：US20170342151A1
公开(公告)日：2017-11-30
申请号：US15526309
申请日：2015-11-12
发明人： Soldano Ferrone , Nai-Kong V. Cheung , Ming Cheng
CPC分类号： C07K16/2809 , A61K2039/505 , C07K16/3053 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/622 , C07K2317/732 , C07K2317/92
摘要： Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of CSPG4-related diseases, in particular, melanoma.
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公开(公告)号：US11091547B2
公开(公告)日：2021-08-17
申请号：US15526309
申请日：2015-11-12
发明人： Soldano Ferrone , Nai-Kong V. Cheung , Ming Cheng
摘要： Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of CSPG4-related diseases, in particular, melanoma.
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