公开(公告)号：US20170135903A1

公开(公告)日：2017-05-18

申请号：US15330061

申请日：2015-01-23

Applicant: EVEON

Inventor： Arnaud Wattelier ,  Xavier Payet-Burin

IPC: A61J1/20 ,  A61J1/14

CPC classification number: A61J1/2093 ,  A61J1/1406 ,  A61J1/20 ,  A61J1/201 ,  A61J1/2017 ,  A61J1/2048 ,  A61J1/2068 ,  A61J1/2086 ,  A61J1/2096 ,  A61M5/142 ,  B65B31/02

Abstract: The invention relates to a device (1) for reconstituting a pharmaceutical composition from at least a first component contained in a first container (2A) and a second component contained in a second container (2B), comprising: a fluidic unit (100) comprising: —a first connector (101) coupled to the first container (2A), —a second connector (102) coupled to the second container (2B), —a pump (103), —a fluidic circuit (104) connecting the first connector (101), the second connector (102) and the pump (103), wherein the first connector (101) comprises a crankpin (1011) in rotating engagement within a body (1010), said crankpin comprising a unique axial port (1011A) intended to fluidically couple to the first container, a radial port (1011B) fluidically connected to said axial port (1011A), and at least one channel (1011C) arranged therein so as to cooperate with the radial ports of the body (1010) to selectively connect the axial port (1011A) of the first connector with at least one channel portion of the fluidic circuit (104) depending on the angular position of the crankpin (1011) with respect to the body (1010), a power unit (200) releasably coupled to the fluidic unit (100), comprising: —a power mechanism (203) for actuating the pump, —transmission means connected between an actuator and the crankpin (1011) for rotating the first container (2A).

公开(公告)号：US10376467B2

公开(公告)日：2019-08-13

申请号：US15112046

申请日：2015-01-20

Applicant: UCB BIOPHARMA SPRL ,  EVEON

Inventor： Xavier Payet-Burin

IPC: A61K9/19 ,  A61K9/00 ,  A61K47/60

Abstract: The invention relates to a process for reconstitution of a solid form of a pharmaceutical composition, comprising the following successive steps: (i) providing the solid form of the pharmaceutical composition in a sealed container, the pressure within the container being an initial pressure (pi,) comprised between 0.5 Pa and 1.2×105 Pa; (ii) at a first time point (t0) introducing the solvent into said sealed container and maintaining the resulting pressure (pr) within the container during a controlled time Δt1; and (iii) at a second time point (t2) increasing the pressure within the container to a controlled pressure (p2) higher than said resulting pressure (pr) until complete reconstitution.

公开(公告)号：US10245213B2

公开(公告)日：2019-04-02

申请号：US15330061

申请日：2015-01-23

Applicant: EVEON

Inventor： Arnaud Wattellier ,  Xavier Payet-Burin

IPC: A61J1/20 ,  A61J1/14 ,  A61M5/142 ,  B65B31/02

Abstract: A device for reconstituting a pharmaceutical composition from at least a first component in a first container and a second component in a second container. The device includes a fluidic unit having a first connector coupled to the first container, a second connector coupled to the second container, a pump, and a fluidic circuit connecting the first connector, the second connector and the pump. The first connector includes a crankpin in rotating engagement within a body and including an axial port fluidically couplable to the first container, a radial port fluidically connected to the axial port of the first connector, and at least one channel arranged therein so as to cooperate with the radial ports of the body of the first connector to selectively connect the axial port of the first connector with at least one channel portion of the fluidic circuit depending on the angular position of the crankpin.