公开(公告)号：US20160083344A1

公开(公告)日：2016-03-24

申请号：US14663990

申请日：2015-03-20

Applicant: EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION

Inventor： Juyoung YOON ,  Jun YIN ,  Gyoungmi KIM ,  Dabin KIM

IPC: C07D209/14 ,  C12Q1/04 ,  C07D401/14 ,  G01N33/68

CPC classification number: C09B23/0066 ,  C07D209/14 ,  C07D401/14 ,  G01N33/6815 ,  G01N2800/26

Abstract: The present invention relates to a compound based on cyanine scaffold for diagnosing sepsis by selectively detecting glutathione. The compound based on cyanine scaffold according to the present invention has the advantages of maintaining its structure in intracellular environment and of reacting selectively to glutathione only among many amino acids containing thiol group (R—SH) such as cysteine, homocysteine, and glutathione, to produce changes in absorption or fluorescence spectrum, making the compound useful for the detection of in vivo glutathione in biosamples and also for the diagnosis of sepsis characteristically displaying the changes of glutathione concentration.

Abstract translation: 本发明涉及一种基于花青支架的化合物，用于通过选择性检测谷胱甘肽来诊断败血症。 根据本发明的基于花青支架的化合物具有将其结构保持在细胞内环境中，并且仅在许多含巯基（R-SH）的氨基酸（如半胱氨酸，高半胱氨酸和谷胱甘肽）中选择性地与谷胱甘肽反应， 产生吸收或荧光光谱的变化，使得该化合物可用于检测生物样品中的体内谷胱甘肽，并且还用于诊断特征性显示谷胱甘肽浓度变化的败血症。