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    EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF
    1.
    发明申请
    EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF 审中-公开

    公开(公告)号：US20170239261A1

    公开(公告)日：2017-08-24

    申请号：US15440655

    申请日：2017-02-23

    Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION

    Inventor： Sang Won KANG ,  Dong Hoon KANG ,  Doo Jae LEE

    IPC: A61K31/548

    CPC classification number: A61K31/548 ,  A61K31/00 ,  C07D513/08 ,  C12Q1/26 ,  G01N2333/90212 ,  G01N2500/02

    Abstract: The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.

    EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF
    2.
    发明申请
    EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF 有权
    苯并二氮草酮化合物或其衍生物及其用途

    公开(公告)号：US20160222031A1

    公开(公告)日：2016-08-04

    申请号：US14286929

    申请日：2014-05-23

    Applicant: EWHA University-Industry Collaboration Foundation

    Inventor： Sang Won KANG ,  Dong Hoon KANG ,  Doo Jae LEE

    IPC: C07D513/08 ,  C12Q1/26

    CPC classification number: A61K31/548 ,  A61K31/00 ,  C07D513/08 ,  C12Q1/26 ,  G01N2333/90212 ,  G01N2500/02

    Abstract: The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.

    Abstract translation: 本发明涉及由以下化学式1表示的硫代二环哌嗪衍生物或其还原衍生物; 一种制备化学式1所示化合物的方法，其具有改善细胞内通透性并模拟细胞中还原形式的2-Cys-Prx的活性; 用于预防或治疗血管疾病的药物组合物，其包含作为活性成分的硫代二环哌嗪化合物或其衍生物或其药学上可接受的盐; 用于局部给药的药物递送装置，包括药物组合物; 以及用于抑制黑素瘤转移的药物组合物，其中所述药物组合物含有作为活性成分的上述二硫代环氧哌嗪化合物或其衍生物或其药学上可接受的盐。

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