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公开(公告)号：US11439640B2
公开(公告)日：2022-09-13
申请号：US16728100
申请日：2019-12-27
Inventor： Sang Won Kang
IPC: A61K31/502 , A61P35/00
Abstract: The present invention relates to a pharmaceutical composition for treating colorectal cancer including a material inhibiting the enzyme activity of peroxiredoxin 2 as an active ingredient, and more specifically, to a pharmaceutical composition for treating colorectal cancer, which exhibits the effect of reducing colon polyps via increase of active β-catenin degradation by inhibiting the activity of peroxiredoxin 2, based on the mechanism that promotes colorectal tumor by the interaction between peroxiredoxin 2 (PrxII) and tankyrase (TNKS) in an APC-mutant cell.
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公开(公告)号：US10045995B2
公开(公告)日：2018-08-14
申请号：US15440655
申请日：2017-02-23
Inventor： Sang Won Kang , Dong Hoon Kang , Doo Jae Lee
IPC: A61K31/535 , A61K31/548
Abstract: The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.
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公开(公告)号：US09765090B2
公开(公告)日：2017-09-19
申请号：US14286929
申请日：2014-05-23
Inventor： Sang Won Kang , Dong Hoon Kang , Doo Jae Lee
IPC: A61K31/54 , C07D513/08 , C12Q1/26 , A61K31/00
CPC classification number: A61K31/548 , A61K31/00 , C07D513/08 , C12Q1/26 , G01N2333/90212 , G01N2500/02
Abstract: The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mimicking the activity of 2-Cys-Prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.
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