公开(公告)号：US20230399397A1

公开(公告)日：2023-12-14

申请号：US17998642

申请日：2020-06-01

Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION

Inventor： Soo Young LEE ,  Hyunbo SHIM ,  Du-ri PARK

IPC: C07K16/28 ,  G01N33/50 ,  A61P19/02

CPC classification number: C07K16/2803 ,  G01N33/5044 ,  A61P19/02 ,  G01N2800/105 ,  A61K2039/505

Abstract: The present application relates to a composition for preventing or treating osteoarthritis, including an osteoclast-associated Ig-like receptor (OSCAR) protein inhibitor, a polynucleotide encoding an anti-OSCAR antibody or a fragment thereof, and an OSCAR protein inhibitor screening method. According to embodiments of the present application, the anti-osteoclast-associated Ig-like receptor (OSCAR) antibody or a fragment thereof of the present application may prevent or treat osteoarthritis through a mechanism for inhibiting the OSCAR-collagen interaction in chondrocytes, and an OSCAR protein inhibitor having an excellent effect of inhibiting the OSCAR-collagen interaction can be screened by using the OSCAR protein inhibitor screening method of the present application.