公开(公告)号：US20230332141A1

公开(公告)日：2023-10-19

申请号：US18173821

申请日：2023-02-24

Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION

Inventor： Hyunbo SHIM ,  Xuelian BAI ,  Moonseon JANG

IPC: C12N15/10 ,  C07K16/00

CPC classification number: C12N15/1089 ,  C07K16/005 ,  C07K2317/565 ,  C07K2317/567

Abstract: The present disclosure relates to a novel method of preparing an antibody library and the prepared library therefrom. The antibody library prepared by the preparation method according to an embodiment of the present disclosure contains antibodies having excellent physical properties to a large number of antigens, and thus can be favorably used as an antibody library that has functional diversity, contains a variety of unique sequences, and also has improved amplification efficiency after panning.

公开(公告)号：US20230399397A1

公开(公告)日：2023-12-14

申请号：US17998642

申请日：2020-06-01

Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION

Inventor： Soo Young LEE ,  Hyunbo SHIM ,  Du-ri PARK

IPC: C07K16/28 ,  G01N33/50 ,  A61P19/02

CPC classification number: C07K16/2803 ,  G01N33/5044 ,  A61P19/02 ,  G01N2800/105 ,  A61K2039/505

Abstract: The present application relates to a composition for preventing or treating osteoarthritis, including an osteoclast-associated Ig-like receptor (OSCAR) protein inhibitor, a polynucleotide encoding an anti-OSCAR antibody or a fragment thereof, and an OSCAR protein inhibitor screening method. According to embodiments of the present application, the anti-osteoclast-associated Ig-like receptor (OSCAR) antibody or a fragment thereof of the present application may prevent or treat osteoarthritis through a mechanism for inhibiting the OSCAR-collagen interaction in chondrocytes, and an OSCAR protein inhibitor having an excellent effect of inhibiting the OSCAR-collagen interaction can be screened by using the OSCAR protein inhibitor screening method of the present application.

公开(公告)号：US20230167184A1

公开(公告)日：2023-06-01

申请号：US17908823

申请日：2021-03-15

Applicant: CUROCELL INC. ,  EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION

Inventor： Hyunbo SHIM ,  Hyung Cheol KIM ,  Mi Kyung KIM

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2878 ,  A61P35/00 ,  C07K2317/565 ,  C07K2319/02 ,  C07K2319/03

Abstract: An embodiment relates to an anti-BCMA-binding protein and, more specifically, provides an isolated BCMA-binding protein comprising an antigen-binding domain that binds specifically to BCMA, wherein the antigen-binding domain comprises: i) heavy chain variable domain complementarity determining region 1 (VH-CDR1) comprising the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 80% homology to SEQ ID NO: 1; ii) VH-CDR2 comprising the amino acid sequence of SEQ ID NO: 2 or an amino acid sequence having at least 80% homology to SEQ ID NO: 2; and iii) VH-CDR3 comprising the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence having at least 80% homology to SEQ ID NO: 3.