公开(公告)号：US20250066662A1

公开(公告)日：2025-02-27

申请号：US18768028

申请日：2024-07-10

Applicant: East China University of Science and Technology

Inventor： Zhiqian GUO ,  Juan LI ,  Yutao ZHANG ,  Yao LU ,  Chenxu YAN ,  Meiling ZHAO ,  Xiuyan ZHAO ,  Weihong ZHU

IPC: C09K11/06 ,  C07D309/34 ,  C07D407/10 ,  G01N21/64

Abstract: A luminescent probe and its preparation method and application are provided. The luminescent probe has a steric hindrance group R1 of aliphatic hydrocarbon structure such as adamantane or norborneol, a detection group R2 of nitrobenzyl and its derivative structure, an electron-withdrawing group R3 containing cyano group and an electron-donating group methoxy group. In the presence of HSA or BSA, the detection group is cut off to form a parent structure that exposes atomic oxygen anions and is activated under external light irradiation, the luminescent probe can be used in solution or cells, when detecting HSA or BSA, the luminescent probe has obvious chemiluminescence characteristics, which can sensitively distinguish HSA and BSA, quantitatively analyze HSA and BSA, and determine the mixing ratio of HSA and BSA at the same time, and the luminescent probe has been successfully used for cell fluorescence imaging.