公开(公告)号：US12023387B2

公开(公告)日：2024-07-02

申请号：US17251961

申请日：2019-06-14

Applicant: THE HONG KONG UNIVERSTIY OF SCIENCE AND TECHNOLOGY ,  HKUST SHENZHEN RESEARCH INSTITUTE

Inventor： Benzhong Tang ,  Pengfei Zhang ,  Jen-Shyang Ni

IPC: A61K49/00 ,  A61B5/00 ,  A61K41/00 ,  C07D309/34 ,  G01N21/64 ,  A61N5/06

CPC classification number: A61K49/0021 ,  A61K41/0057 ,  C07D309/34 ,  G01N21/6428 ,  G01N21/6456 ,  A61B5/0071 ,  A61N5/062 ,  G01N2021/6439

Abstract: Small molecule compounds having aggregation-induced emission (AIE) characteristics include donor-acceptor (D-A) structural NIR fluorophores based on 1,3-bis(dicyanomethylene)indan (BDCI), a strong and steric electron-deficient acceptor. A twisted quasi-double bond (TQDB) links each electron donor with the acceptor. The compounds can be used as NIR-II fluorescent dyes for in vivo imaging. The compounds can conjugate with bioactive molecules, such as peptides, sugars, aptamers and antibodies, to provide specific and active NIR-II fluorescent probes. The compounds can serve as active NIR-II fluorescent probes in many applications, such as, cancer cell-targeted imaging, accurate diagnosis of disease, and image-guided phototherapy.

公开(公告)号：US11760765B2

公开(公告)日：2023-09-19

申请号：US16950906

申请日：2020-11-18

Applicant: Covestro Deutschland AG

Inventor： Thomas Rölle ,  Horst Berneth ,  Dennis Hönel ,  Friedrich-Karl Bruder ,  Jürgen Kintrup

IPC: C07F5/02 ,  C07F5/04 ,  C07C211/63 ,  C07C211/64 ,  C07C217/08 ,  C07C219/10 ,  C07C219/28 ,  C07C219/30 ,  C07C271/12 ,  C07C271/20 ,  C07C271/24 ,  C07D213/20 ,  C07D233/58 ,  C07D295/037 ,  C07D413/06 ,  C07F9/54 ,  G03F7/00 ,  C07C271/28 ,  C07D347/00 ,  C07D233/02 ,  C07D247/00 ,  C07D335/02 ,  C07C271/16 ,  C07D309/34

CPC classification number: C07F5/027 ,  C07C211/63 ,  C07C211/64 ,  C07C217/08 ,  C07C219/10 ,  C07C219/28 ,  C07C219/30 ,  C07C271/12 ,  C07C271/16 ,  C07C271/20 ,  C07C271/24 ,  C07C271/28 ,  C07D213/20 ,  C07D233/02 ,  C07D233/58 ,  C07D247/00 ,  C07D295/037 ,  C07D309/34 ,  C07D335/02 ,  C07D347/00 ,  C07D413/06 ,  C07F5/04 ,  C07F9/54 ,  C07F9/5407 ,  C07F9/5442 ,  G03F7/001 ,  C07C2601/14

Abstract: The invention relates to a process for preparing triaryl organoborates proceeding from organoboronic esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms.

公开(公告)号：US20230088213A1

公开(公告)日：2023-03-23

申请号：US17642219

申请日：2020-09-11

Applicant: IDEMITSU KOSAN CO.,LTD.

Inventor： Satomi TASAKI ,  Kazuki NISHIMURA ,  Yuki NAKANO

IPC: C07C15/38 ,  C07D307/91 ,  C07D333/76 ,  C07C15/28 ,  C07C15/30 ,  C07C15/20 ,  C07D309/34 ,  C07D407/10 ,  C07F7/08 ,  C07C211/54 ,  C07D471/06 ,  C07D487/06 ,  C07D491/16 ,  C07D491/22 ,  C07D487/16 ,  C07D495/22 ,  C07D487/22 ,  C07F5/02 ,  C07D493/04 ,  C07D495/04 ,  C07D409/04 ,  H01L51/00 ,  H01L51/50 ,  C09K11/06

Abstract: An organic electroluminescence device includes an anode, a cathode, a first emitting layer, and a second emitting layer provided between the first emitting layer and the cathode, in which the first emitting layer contains a first compound represented by a formula (101) below as a first host material, the second emitting layer contains a second compound represented by a formula (2) below as a second host material, and the first emitting layer is in direct contact with the second emitting layer.

公开(公告)号：US20220002321A1

公开(公告)日：2022-01-06

申请号：US16950906

申请日：2020-11-18

Applicant: Covestro Deutschland AG

Inventor： Thomas RÖLLE ,  Horst BERNETH ,  Dennis HÖNEL ,  Friedrich-Karl BRUDER ,  Jürgen KINTRUP

IPC: C07F5/02 ,  C07C211/63 ,  C07C211/64 ,  C07C217/08 ,  C07C219/10 ,  C07C219/28 ,  C07C219/30 ,  C07C271/12 ,  C07C271/20 ,  C07C271/24 ,  C07D213/20 ,  C07D233/58 ,  C07D295/037 ,  C07D413/06 ,  C07F5/04 ,  C07F9/54 ,  G03F7/00 ,  C07C271/28 ,  C07D347/00 ,  C07D233/02 ,  C07D247/00 ,  C07D335/02 ,  C07C271/16 ,  C07D309/34

Abstract: The invention relates to a process for preparing triaryl organoborates proceeding from organoboronic esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms.

公开(公告)号：US11098066B2

公开(公告)日：2021-08-24

申请号：US16348309

申请日：2017-11-07

Applicant: Covestro Deutschland AG

Inventor： Thomas Rölle ,  Horst Berneth ,  Dennis Hönel ,  Friedrich-Karl Bruder ,  Jürgen Kintrup

IPC: C07F5/00 ,  C07C271/00 ,  C07C219/00 ,  C07C217/00 ,  C07C211/00 ,  C07F5/02 ,  C07C211/63 ,  C07C211/64 ,  C07C217/08 ,  C07C219/10 ,  C07C219/28 ,  C07C219/30 ,  C07C271/12 ,  C07C271/20 ,  C07C271/24 ,  C07D213/20 ,  C07D233/58 ,  C07D295/037 ,  C07D413/06 ,  C07F5/04 ,  C07F9/54 ,  G03F7/00 ,  C07C271/28 ,  C07D347/00 ,  C07D233/02 ,  C07D247/00 ,  C07D335/02 ,  C07C271/16 ,  C07D309/34

Abstract: Provided herein is a process for preparing triaryl organoborates of the formula 1/n Kn+R34B−—R1 (IV), where one equivalent of organoboronic ester of the formula B—R1(OR2)(OR3) (I) is initially charged together with 1/n equivalents of salt Kn+ nX− (II) and 3 equivalents of metal M in a solvent or a solvent mixture S1, 3 equivalents of a haloaromatic R4—Y (III) are added, an auxiliary L and optionally a second organic solvent or solvent mixture S2 is added and the compound 1/n Kn+ R34B−—R1 (IV) is separated off with the organic phase, and to the use of these substances as co-initiator in photopolymer formulations.

公开(公告)号：US10208009B2

公开(公告)日：2019-02-19

申请号：US15780421

申请日：2016-11-30

Applicant: AMOREPACIFIC CORPORATION

Inventor： Ho Sik Rho ,  Jae Won Yoo ,  Yong Jin Kim

IPC: C07D309/40 ,  A61Q19/08 ,  A61K8/49 ,  C07D309/34

Abstract: The present invention relates to a novel hydroxyl pyranone compound, a method for producing same, and a cosmetic composition having the compound. The hydroxyl pyranone compound according to the present invention exhibits markedly improved effectiveness compared to the conventional adipocyte differentiation-promoting material, and thus is preferably included as an active ingredient in a cosmetic composition for increasing skin volume or elasticity.

公开(公告)号：US20190002426A1

公开(公告)日：2019-01-03

申请号：US16064276

申请日：2016-12-20

Applicant: University of Maryland, Baltimore

Inventor： Erik de Leeuw ,  Alexander MacKerell ,  Steven Fletcher ,  Jamal Chauhan

IPC: C07D309/34 ,  C07D403/06 ,  C07D471/06 ,  A61P31/04

Abstract: Newly synthesized derivatives of BAS00127538 have been discovered to possess antibiotic activity and to combat resistant bacterial strains. Compounds and pharmaceutical compositions containing these compounds are described, and are based on a generic scaffold structure. Synthetic methods and methods of using the compounds also are described. Preferred compound 6jc48-1 ((E)-2,4-bis(4-bromophenyl)-6-(4-(dimethyl-amino)styryl)pyrylium boron tetrafluoride salt) binds to Lipid II with high affinity, has markedly reduced cytotoxicity than BAS00127538, and retains activity against drug-resistant strains of Enterococci. It is stable in plasma, has dramatically improved pharmacokinetic and pharmacodynamics properties, and possesses in vivo efficacy in a mouse model of sepsis.

公开(公告)号：US09642829B2

公开(公告)日：2017-05-09

申请号：US14095757

申请日：2013-12-03

Applicant: The University of Hong Kong

Inventor： Chaminda Jayampath Seneviratne ,  Yi Tsun Richard Kao ,  Lakshman Perera Samaranayake ,  Kwok Yung Yuen ,  Dan Yang ,  Yu Wang ,  Sze Wah Sarah Wong

IPC: C07D309/34 ,  A61K31/351 ,  A01N43/40 ,  A01N59/00 ,  A61K9/00 ,  A61K9/08

CPC classification number: A61K31/351 ,  A01N43/40 ,  A01N59/00 ,  A61K9/0019 ,  A61K9/08 ,  A01N25/34

Abstract: Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.

公开(公告)号：US6156506A

公开(公告)日：2000-12-05

申请号：US825586

申请日：1997-04-01

Applicant: Nobuko Yamamoto ,  Tadashi Okamoto

Inventor： Nobuko Yamamoto ,  Tadashi Okamoto

IPC: C07D309/34 ,  C12Q1/68 ,  G01N33/533 ,  G01N33/58

CPC classification number: G01N33/582 ,  C07D309/34 ,  C12Q1/6818 ,  G01N33/533

Abstract: A method for detecting a target substance in a sample comprises the steps of providing at least two reagents which can form a reaction system for causing changes as the result of an interaction therebetween the interaction being caused only when the target substance is present in the sample, reacting the reagents with the target substance, and measuring the resulting changes based on the interaction, wherein at least one of the reagents forming the reaction system is selected from specific pyrylium compounds.

Abstract translation: 用于检测样品中目标物质的方法包括以下步骤：提供至少两种试剂，其可以形成用于引起作为其之间相互作用的结果的变化的反应体系，所述相互作用仅在样品中存在目标物质时引起 使试剂与目标物质反应，并根据相互作用测量所得的变化，其中形成反应体系的至少一种试剂选自特定的吡喃鎓化合物。

公开(公告)号：US5880287A

公开(公告)日：1999-03-09

申请号：US476544

申请日：1995-06-07

Applicant: Walter B. Dandliker ,  Robert Francis Devlin ,  Peter Olaf Gustaf Arrhenius ,  Mao-Lin Hsu

Inventor： Walter B. Dandliker ,  Robert Francis Devlin ,  Peter Olaf Gustaf Arrhenius ,  Mao-Lin Hsu

IPC: G01N33/533 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  C07D209/14 ,  C07D209/60 ,  C07D215/12 ,  C07D241/38 ,  C07D277/64 ,  C07D309/34 ,  C07D311/58 ,  C07D335/02 ,  C07D409/06 ,  C07D421/06 ,  C07D487/22 ,  C07J43/00 ,  C07J51/00 ,  C09B47/00 ,  C09B47/04 ,  C09B47/073 ,  C09B47/08 ,  C09B47/24 ,  C09B69/00 ,  G01N33/52 ,  G01N33/58 ,  C09B23/00 ,  C07D513/02

CPC classification number: A61K41/0057 ,  A61K47/48215 ,  A61K49/0015 ,  A61K49/0021 ,  A61K49/0026 ,  A61K49/0028 ,  A61K49/003 ,  A61K49/0032 ,  C07D487/22 ,  C07J43/003 ,  C07J51/00 ,  C09B47/00 ,  C09B47/045 ,  C09B47/073 ,  C09B47/08 ,  C09B47/24 ,  C09B69/00 ,  G01N33/52 ,  G01N33/533 ,  G01N33/582 ,  G01N2333/19

Abstract: Fluorescent dyes which are free of aggregation and serum binding are provided. These dyes are suitable for applications such as fluorescence immunoassays, in vivo imaging and in vivo tumor therapy. Fluorescence immunoassays methods are provided which use fluorescent dyes which are free of aggregation and serum binding. Such immunoassay methods are thus, particularly useful for the assay of biological fluids, such as serum, plasma, whole blood and urine. The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.

Abstract translation: 提供了没有聚集和血清结合的荧光染料。 这些染料适用于荧光免疫测定，体内成像和体内肿瘤治疗。 提供荧光免疫测定方法，其使用不含聚集和血清结合的荧光染料。 因此，这样的免疫测定方法对生物流体如血清，血浆，全血和尿液的测定特别有用。 本发明涉及包含连接到包含荧光团部分的可检测标记的标记组分的寡核苷酸的组合物，其包含与能够与两个轴向配体和两个聚氧化烃部分配位的中心原子配位的基本上平面的多齿大环配体， 轴向配体到中心原子。 本发明还涉及使用这种组合物的核酸杂交和扩增方法。