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1.发明授权Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions 有权二氢蝶啶酮，其制备方法及其作为药物组合物的用途公开(公告)号：US06806272B2
公开(公告)日：2004-10-19
申请号：US10226710
申请日：2002-08-23
申请人： Eckhart Bauer , Steffen Breitfelder , Christian Eickmeier , Matthias Grauert , Matthias Hoffmann , Thorsten Lehmann-Lintz , Gerald Pohl , Jens Quant , Norbert Redemann , Gisela Schnapp , Martin Steegmaier
发明人： Eckhart Bauer , Steffen Breitfelder , Christian Eickmeier , Matthias Grauert , Matthias Hoffmann , Thorsten Lehmann-Lintz , Gerald Pohl , Jens Quant , Norbert Redemann , Gisela Schnapp , Martin Steegmaier
IPC分类号： C07D48704
CPC分类号： C07D487/04 , C07D475/00
摘要： The present invention relates to new dihydropteridinones of the formula (I) wherein the groups X, R1, R2, R3, R4, R5 and R7 have the meanings given in the claims and the specification, the isomers thereof, processes and intermediates for preparing these dihydropteridinones as well as the use thereof as pharmaceutical compositions.
摘要翻译： 本发明涉及式（I）的新的二氢蝶啶酮，其中基团X，R 1，R 2，R 3，R 4，R 5和R 7具有如下含义： 权利要求书和说明书中给出的其异构体，用于制备这些二氢蝶啶烷酮的方法和中间体以及其作为药物组合物的用途。
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2.发明申请Methods of treating diseases or conditions using dihydropteridinone compounds 审中-公开使用二氢蝶啶酮化合物治疗疾病或病症的方法公开(公告)号：US20050014760A1
公开(公告)日：2005-01-20
申请号：US10903807
申请日：2004-07-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , A61K31/525
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶呤的中间体和方法及其用途 药物组合物。
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3.发明申请Intermediate compounds for making dihydropteridinones useful as pharmaceutical compositions 审中-公开用作制备二氢蝶啶酮的中间体化合物，可用作药物组合物公开(公告)号：US20050014761A1
公开(公告)日：2005-01-20
申请号：US10909008
申请日：2004-07-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , A61K31/525 , C07D475/02
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶呤的中间体和方法及其用途 药物组合物。
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4.发明申请New dihydropteridione derivatives, process for their manufacture and their use as medicament 有权新的二氢二萜衍生物，其制备方法及其作为药物的用途公开(公告)号：US20060052383A1
公开(公告)日：2006-03-09
申请号：US11210951
申请日：2005-08-24
申请人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Quant
发明人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Quant
IPC分类号： A61K31/525 , C07D475/02
CPC分类号： C07D487/04 , C07D475/00 , Y02P20/55
摘要： Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，
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5.发明授权Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions 有权二氢蝶啶酮，其制备方法及其作为药物组合物的用途公开(公告)号：US06861422B2
公开(公告)日：2005-03-01
申请号：US10374876
申请日：2003-02-26
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61P35/00 , C07D475/00 , C07D519/00 , C07D487/04 , A61K31/4985
CPC分类号： C07D295/073 , C07D475/00
摘要： The present invention relates to new dihydropteridinones of general formula (I): wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新的二氢蝶啶酮：其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶的方法和用途 作为药物组合物。
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公开(公告)号：US20080293944A1
公开(公告)日：2008-11-27
申请号：US12129728
申请日：2008-05-30
申请人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffmann , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： C07D241/04
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的中间体和方法及其作为药物组合物的用途。
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7.发明授权Dihydropteridione derivatives, process for their manufacture and their use as medicament 有权二氢丙啶衍生物，其制备方法及其作为药物的用途公开(公告)号：US07332491B2
公开(公告)日：2008-02-19
申请号：US11210951
申请日：2005-08-24
申请人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Juergen Quant
发明人： Matthias Grauert , Matthias Hoffmann , Martin Steegmaier , Christian Eickmeier , Gisela Schnapp , Norbert Redemann , Flavio Solca , Jens Juergen Quant
IPC分类号： A61K31/541 , A61K31/5025 , A61K31/4985 , C07D273/01 , C07D471/04 , C07D487/04 , C07D491/04 , C07D475/12 , A61P19/02
CPC分类号： C07D487/04 , C07D475/00 , Y02P20/55
摘要： Disclosed are new dihydropteridinones of general formula (I) whereby the groups L, R1, R2, R3, R4 and R5 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these dihydropteridinones and their use as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L，R 1，R 2，R 3，R 4， ＆lt; 5＆gt;和＆lt; 5＆gt;具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶的方法及其作为药物组合物的用途。
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8.发明授权2-benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments 有权2-苄基氨基二氢蝶啶酮，其制备方法和用途作为药物公开(公告)号：US07759347B2
公开(公告)日：2010-07-20
申请号：US12357731
申请日：2009-01-22
申请人： Matthias Hoffmann , Matthias Grauert , Thorsten Lehmann-Lintz , Martin Steegmaier , Flavio Solca , Norbert Redemann
发明人： Matthias Hoffmann , Matthias Grauert , Thorsten Lehmann-Lintz , Martin Steegmaier , Flavio Solca , Norbert Redemann
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495 , C07D475/00
CPC分类号： C07D475/00
摘要： The present invention relates to new 2-benzylaminodihydropteridinones of general formula (I) wherein the groups R1 to R7, R10 and R11 have the meanings given in the claims and specification, the isomers thereof, methods of preparing these dihydropteridinones and their use as medicaments.
摘要翻译： 本发明涉及通式（I）的新的2-苄基氨基二氢蝶啶酮，其中基团R 1至R 7，R 10和R 11具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶烷的方法及其作为药物的用途。
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9.发明申请2-Benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments 审中-公开2-苄基氨基二氢蝶啶酮，其制备方法和用作药物公开(公告)号：US20060004014A1
公开(公告)日：2006-01-05
申请号：US11157883
申请日：2005-06-21
申请人： Matthias Hoffmann , Matthias Grauert , Thorsten Lehmann-Lintz , Martin Steegmaier , Flavio Solca , Norbert Redemann
发明人： Matthias Hoffmann , Matthias Grauert , Thorsten Lehmann-Lintz , Martin Steegmaier , Flavio Solca , Norbert Redemann
IPC分类号： A61K31/525 , C07D475/06
CPC分类号： C07D475/00
摘要： The present invention relates to new 2-benzylaminodihydropteridinones of general formula (I) wherein the groups R1 to R7, R10 and R11 have the meanings given in the claims and specification, the isomers thereof, methods of preparing these dihydropteridinones and their use as medicaments.
摘要翻译： 本发明涉及通式（I）的新的2-苄基氨基二氢蝶啶酮，其中基团R 1至R 7，R 10和R 10， SUP> 11 具有权利要求书和说明书中给出的含义，其异构体，制备这些二氢蝶啶酮的方法及其作为药物的用途。
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10.发明申请Intermediate Compounds for making Dihydropteridinones Useful as Pharmaceutical Compositions 有权用作制备二氢蝶呤的中间体化合物可用作药物组合物公开(公告)号：US20080171747A1
公开(公告)日：2008-07-17
申请号：US11941463
申请日：2007-11-16
申请人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
发明人： Matthias Hoffman , Matthias Grauert , Trixi Brandl , Steffen Breitfelder , Christian Eickmeier , Martin Steegmaier , Gisela Schnapp , Anke Baum , Jens Juergen Quant , Flavio Solca , Florian Colbatzky
IPC分类号： A61K31/525 , C07D475/02
CPC分类号： C07D295/073 , C07D475/00
摘要： Disclosed are new dihydropteridinones of general formula (I) wherein the groups L and R1-R5 have the meanings given in the claims and specification, the isomers thereof, intermediates and processes for preparing these dihydropteridinones and the use thereof as pharmaceutical compositions.
摘要翻译： 公开了通式（I）的新的二氢蝶啶酮，其中基团L和R 1 -R 5具有权利要求和说明书中给出的含义，其异构体，中间体和 制备这些二氢蝶啶酮的方法及其作为药物组合物的用途。
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