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1.发明授权Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells 失效使用树突状细胞激活γ/δ-T细胞受体阳性T细胞的方法公开(公告)号：US06821778B1
公开(公告)日：2004-11-23
申请号：US08610195
申请日：1996-02-28
IPC分类号： C12N508
CPC分类号： C12N5/0636 , A61K2039/5158 , A61K2039/57
摘要： This invention relates to methods of using human dendritic cells to present antigens for the induction of antigen-specific T cell-mediated immune responses. In particular, it relates to the isolation of dendritic cells from human blood, exposing the cells to antigens, co-culturing the antigen-pulsed dendritic cells with &ggr;&dgr;-T cell receptor-positive-T cells (&ggr;&dgr;-TCR+ T cells) obtained from unprimed or weakly primed individuals for the stimulation of antigen-specific T cell proliferative and cytotoxic activities. The dendritic cell antigen presentation system described herein has a wide range of applications, including but not limited to, activation and expansion of large numbers of antigen-specific major histocompatibility complex-unrestricted T cells for use in adoptive cellular immunotherapy against infectious diseases and cancer.
摘要翻译： 本发明涉及使用人树突状细胞呈递抗原以诱导抗原特异性T细胞介导的免疫应答的方法。 特别地，它涉及从人血液中分离树突状细胞，将细胞暴露于抗原，用gammadelta-T细胞受体阳性T细胞（gammadelta-TCR + T细胞）共同培养抗原脉冲的树突状细胞 ）从未引导或弱引发的个体获得，用于刺激抗原特异性T细胞增殖和细胞毒活性。 本文描述的树突状细胞抗原呈递系统具有广泛的应用，包括但不限于大量抗原特异性主要组织相容性复合物无限制T细胞的活化和扩增，用于针对传染病和癌症的过继细胞免疫治疗。
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公开(公告)号：US09365633B2
公开(公告)日：2016-06-14
申请号：US13992023
申请日：2011-12-06
IPC分类号： C07K14/78 , C07K7/06 , C07K7/08 , C07K14/435 , A61K38/00
CPC分类号： C07K14/78 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/435
摘要： The subject of the present invention are peptide preparations obtained via the enzymatic digestion of hair, wool, bristles, animal fur and individual peptides with sequences corresponding to individual components of a peptide preparation with antitumor activity, for use in the treatment of tumors or oncological prophylaxis as basal components or components of compositions of substances for treating tumors or components of substances used in oncological prophylaxis.
摘要翻译： 本发明的主题是通过酶促消化头发，羊毛，刷毛，动物毛皮和具有对应于具有抗肿瘤活性的肽制剂的各个成分的序列的单独肽获得的肽制剂，用于治疗肿瘤或肿瘤预防 作为用于治疗肿瘤的物质组合物的基础组分或组分或用于肿瘤预防的物质的组分。
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公开(公告)号：US20140315824A1
公开(公告)日：2014-10-23
申请号：US13992023
申请日：2011-12-06
CPC分类号： C07K14/78 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/435
摘要： The subject of the present invention are peptide preparations obtained via the enzymatic digestion of hair, wool, bristles, animal fur and individual peptides with sequences corresponding to individual components of a peptide preparation with antitumour activity, for use in the treatment of tumours or oncological prophylaxis as basal components or components of compositions of substances for treating tumours or components of substances used in oncological prophylaxis.
摘要翻译： 本发明的主题是通过酶促消化毛发，羊毛，鬃毛，动物毛皮和具有对应于具有抗肿瘤活性的肽制剂的各成分的序列的单独肽获得的肽制剂，用于治疗肿瘤或肿瘤预防 作为用于治疗肿瘤的物质组合物的基础组分或组分或用于肿瘤预防的物质的组分。
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