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1.发明申请Method of screening compounds for potential efficacy for the treatment of signs of aging 审中-公开筛选化合物治疗老化迹象的潜在疗效的方法公开(公告)号：US20060193777A1
公开(公告)日：2006-08-31
申请号：US11066361
申请日：2005-02-25
申请人： Michael Southall , Eduardo Ruvolo , Binoy Bordoloi , Katharine Martin , Nikiforos Kollias , Elvin Lukenbach , Gloria Lukenbach
发明人： Michael Southall , Eduardo Ruvolo , Binoy Bordoloi , Katharine Martin , Nikiforos Kollias , Elvin Lukenbach , Gloria Lukenbach
CPC分类号： G01N33/5044 , A61K49/0006 , G01N33/5026
摘要： The present invention features a method of screening a compound for potential efficacy for the treatment of at least one sign of aging on the skin selected from the group consisting of enhancing the elasticity of said skin, enhancing the firmness of said skin, or reducing the appearance of wrinkles on the skin, said method comprising contacting one or more skin cells with said compound and measuring the ability of said compound to contract said one or more skin cells.
摘要翻译： 本发明的特征在于一种筛选化合物的方法，用于治疗选自以下的至少一种皮肤老化迹象的潜在功效：选自增强所述皮肤的弹性，增强所述皮肤的硬度或减少外观 所述方法包括使一种或多种皮肤细胞与所述化合物接触并测量所述化合物收缩所述一种或多种皮肤细胞的能力。
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公开(公告)号：US20060193814A1
公开(公告)日：2006-08-31
申请号：US11066362
申请日：2005-02-25
IPC分类号： A61K8/41
摘要： The present invention features a method of treating at least one sign of aging on the skin selected from the group consisting of enhancing the elasticity of said skin, enhancing the firmness of said skin, and reducing the appearance of wrinkles or cellulite on the skin, by administering to skin in need of such treatment a composition comprising at least one compound of the formula I or formula II: wherein R1, R2, R3, R4, and R5 independently, are selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, or a cosmetically acceptable salt thereof.
摘要翻译： 本发明的特征在于一种治疗至少一种皮肤老化迹象的方法，所述衰老迹象选自由增强皮肤弹性，增强皮肤紧致度，减少皮肤上皱纹或脂肪团出现的组成， 向需要这种治疗的皮肤施用包含至少一种式I或式II化合物的组合物：其中R 1，R 2，R 3，R 4和R 5独立地选自氢，C 1 C 1 -C 6烷基，C 1 -C 6羟基烷基或其化妆品可接受的盐。
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公开(公告)号：US20090292027A1
公开(公告)日：2009-11-26
申请号：US12534214
申请日：2009-08-03
申请人： Eduardo Ruvolo , Michael D. Southall , Binoy K. Bordoloi , Elvin R. Lukenbach , Gloria Jean Lukenbach
发明人： Eduardo Ruvolo , Michael D. Southall , Binoy K. Bordoloi , Elvin R. Lukenbach , Gloria Jean Lukenbach
IPC分类号： A61K8/41 , A61K31/133 , A61Q19/08
摘要： The present invention features a method of treating at least one sign of aging on the skin selected from the group consisting of enhancing the elasticity of said skin, enhancing the firmness of said skin, and reducing the appearance of wrinkles or cellulite on the skin, by administering to skin in need of such treatment a composition comprising at least one compound of the formula I or formula II: wherein R1, R2, R3, R4, and R5 independently, are selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, or a cosmetically acceptable salt thereof.
摘要翻译： 本发明的特征在于一种治疗至少一种皮肤老化迹象的方法，所述衰老迹象选自由增强皮肤弹性，增强皮肤紧致度，减少皮肤上皱纹或脂肪团出现的组成， 向需要这种治疗的皮肤施用包含至少一种式I或式II化合物的组合物：其中R 1，R 2，R 3，R 4和R 5独立地选自氢，C 1 -C 6烷基， C1-C6羟基烷基或其化妆品可接受的盐。
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4.发明申请公开(公告)号：US20060210351A1
公开(公告)日：2006-09-21
申请号：US11084921
申请日：2005-03-21
CPC分类号： A45D34/04 , A45D2200/055 , A45D2200/207 , B43M11/04 , B43M11/06
摘要： The invention features a device for applying a fluid composition to the skin, said device including (i) a reservoir containing said composition, said composition including at least one tensioning polymer and (ii) a skin-contactable surface having at least one opening, wherein said device is adapted such that said fluid composition may be extruded from such reservoir to said skin-contacting surface through said at least one openings.
摘要翻译： 本发明的特征在于一种用于将流体组合物施用于皮肤的装置，所述装置包括（i）包含所述组合物的储存器，所述组合物包括至少一个张紧聚合物和（ii）具有至少一个开口的皮肤接触表面，其中 所述装置适于使得所述流体组合物可以通过所述至少一个开口从所述储存器挤出到所述皮肤接触表面。
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5.发明授权公开(公告)号：US08157467B2
公开(公告)日：2012-04-17
申请号：US11084921
申请日：2005-03-21
申请人： Donald P. Losier , Joseph Luizzi , Candelario A. Fernandez, Jr. , Claudia Kaminski , Eduardo Ruvolo
发明人： Donald P. Losier , Joseph Luizzi , Candelario A. Fernandez, Jr. , Claudia Kaminski , Eduardo Ruvolo
IPC分类号： B05C11/00
CPC分类号： A45D34/04 , A45D2200/055 , A45D2200/207 , B43M11/04 , B43M11/06
摘要： The invention features a device for applying a fluid composition to the skin, said device including (i) a reservoir containing said composition, said composition including at least one tensioning polymer and (ii) a skin-contactable surface having at least one opening, wherein said device is adapted such that said fluid composition may be extruded from such reservoir to said skin-contacting surface through said at least one openings.
摘要翻译： 本发明的特征在于一种用于将流体组合物施用于皮肤的装置，所述装置包括（i）包含所述组合物的储存器，所述组合物包括至少一个张紧聚合物和（ii）具有至少一个开口的皮肤接触表面，其中 所述装置适于使得所述流体组合物可以通过所述至少一个开口从所述储存器挤出到所述皮肤接触表面。
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公开(公告)号：US08344031B2
公开(公告)日：2013-01-01
申请号：US12534214
申请日：2009-08-03
申请人： Eduardo Ruvolo , Michael D. Southall , Binoy K. Bordoloi , Elvin R. Lukenbach , Gloria Jean Lukenbach, legal representative
IPC分类号： A61K8/41 , A61K31/133 , A61Q19/08
摘要： The present invention features a method of treating at least one sign of aging on the skin selected from the group consisting of enhancing the elasticity of said skin, enhancing the firmness of said skin, and reducing the appearance of wrinkles or cellulite on the skin, by administering to skin in need of such treatment a composition comprising at least one compound of the formula I or formula II: wherein R1, R2, R3, R4, and R5 independently, are selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 hydroxyalkyl, or a cosmetically acceptable salt thereof.
摘要翻译： 本发明的特征在于一种治疗至少一种皮肤老化迹象的方法，所述衰老迹象选自由增强皮肤弹性，增强皮肤紧致度，减少皮肤上皱纹或脂肪团出现的组成， 向需要这种治疗的皮肤施用包含至少一种式I或式II化合物的组合物：其中R 1，R 2，R 3，R 4和R 5独立地选自氢，C 1 -C 6烷基， C1-C6羟基烷基或其化妆品可接受的盐。
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7.发明授权Imaging apparatus and methods for capturing and analyzing digital images of the skin 有权用于捕获和分析皮肤数字图像的成像设备和方法公开(公告)号：US07764303B2
公开(公告)日：2010-07-27
申请号：US11863342
申请日：2007-09-28
CPC分类号： H04N5/2354 , A61B5/0059 , A61B5/441 , G03B15/07 , H04N5/2252 , H04N9/045
摘要： An imaging station for taking a plurality of digital images of a subject under a plurality of illuminating conditions and storing and analyzing the digital images, includes a housing, containing the digital image capturing apparatus, like a camera or video recorder, a computer for processing the image data and one or more displays for displaying images of the person. The imaging station aids in controlling lighting during image capture and may be used to optimally position the subject for imaging. The computer may be programmed to conduct various image processing functions and may be networked to allow image sharing. A display which may be provided on the exterior of the housing allows an operator to visualize the subject and to control the imaging process. The imaging station may be used for teaching purposes.
摘要翻译： 一种用于在多个照明条件下拍摄对象的多个数字图像并存储和分析数字图像的成像站包括容纳数字图像捕获装置的外壳，如摄像机或录像机，用于处理 图像数据和用于显示人的图像的一个或多个显示器。 成像站有助于在图像捕获期间控制照明，并且可以用于最佳地定位被摄体以进行成像。 计算机可以被编程为执行各种图像处理功能，并且可以联网以允许图像共享。 可以设置在外壳的外部的显示器允许操作者可视化对象并控制成像处理。 成像站可用于教学目的。
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8.发明申请Imaging Apparatus and Methods for Capturing and Analyzing Digital Images of the Skin 有权用于捕获和分析皮肤数字图像的成像装置和方法公开(公告)号：US20080079843A1
公开(公告)日：2008-04-03
申请号：US11863342
申请日：2007-09-28
CPC分类号： H04N5/2354 , A61B5/0059 , A61B5/441 , G03B15/07 , H04N5/2252 , H04N9/045
摘要： An imaging station for taking a plurality of digital images of a subject under a plurality of illuminating conditions and storing and analyzing the digital images, includes a housing, containing the digital image capturing apparatus, like a camera or video recorder, a computer for processing the image data and one or more displays for displaying images of the person. The imaging station aids in controlling lighting during image capture and may be used to optimally position the subject for imaging. The computer may be programmed to conduct various image processing functions and may be networked to allow image sharing. A display which may be provided on the exterior of the housing allows an operator to visualize the subject and to control the imaging process. The imaging station may be used for teaching purposes.
摘要翻译： 一种用于在多个照明条件下拍摄对象的多个数字图像并存储和分析数字图像的成像站包括容纳数字图像捕获装置的外壳，如摄像机或录像机，用于处理 图像数据和用于显示人的图像的一个或多个显示器。 成像站有助于在图像捕获期间控制照明，并且可以用于最佳地定位被摄体以进行成像。 计算机可以被编程为执行各种图像处理功能，并且可以联网以允许图像共享。 可以设置在外壳的外部的显示器允许操作者可视化对象并控制成像处理。 成像站可用于教学目的。
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公开(公告)号：US20060052719A1
公开(公告)日：2006-03-09
申请号：US10937039
申请日：2004-09-09
申请人： Eduardo Ruvolo , Nikiforos Kolias , Curtis Cole
发明人： Eduardo Ruvolo , Nikiforos Kolias , Curtis Cole
IPC分类号： A61B5/00
CPC分类号： A61B5/442 , A61B5/0051
摘要： The present invention relates to a method of determining skin anisotropy of a subject by measuring rates of propagation of mechanical energy between a mechanical energy generator and a mechanical energy detector along a plurality of directions of an expanse of skin wherein each of the directions are from about 0° to about 10° in separation relative at least one other of the directions and at least two of the directions are from about 30° to about 180° in separation relative to each other.
摘要翻译： 本发明涉及一种通过测量机械能量发生器和机械能量检测器之间的机械能的传播速率来确定受试者的皮肤各向异性的方法，所述机械能量沿着皮肤的多个方向的多个方向，其中每个方向为约 0°至约10°，相对于彼此分离，至少另一个方向和至少两个方向分离为约30°至约180°。
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