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公开(公告)号：US20160022470A1
公开(公告)日：2016-01-28
申请号：US14877862
申请日：2015-10-07
CPC分类号： A61F5/56 , A61F2/00 , A61F5/566 , A61F2210/0004 , A61F2210/0057
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body has a V-shape with first and second elongated legs configured for implantation in airway-interface tissue. The first and second elongated legs are configured to apply tensile forces to the tissue. Methods of using such systems are also provided.
摘要翻译： 一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。 在一些实施例中，植入物本体具有V形，其中第一和第二细长腿构造成用于植入气道界面组织中。 第一和第二细长腿构造成对组织施加张力。 还提供了使用这种系统的方法。
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公开(公告)号：US20140246027A1
公开(公告)日：2014-09-04
申请号：US14275426
申请日：2014-05-12
IPC分类号： A61F5/56
CPC分类号： A61F5/566 , A61F2/00 , A61F5/56 , A61F2210/0004
摘要： A system for treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, the implant body includes an adjustment element configured to allow in-situ adjustment of the implant body between first and second tensioning forces applied to the site. Methods of using such systems are also provided.
摘要翻译： 一种用于治疗气道障碍的系统设置有植入体，其构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。 在一些实施例中，植入物主体包括调整元件，其被配置为允许植入物本体在施加到部位的第一和第二张力之间进行原位调整。 还提供了使用这种系统的方法。
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公开(公告)号：US20170216083A1
公开(公告)日：2017-08-03
申请号：US15263296
申请日：2016-09-12
申请人： Edward M. GILLIS , John H. SHADDUCK , Csaba TRUCKAI , Andrew POUTIATINE , Paul J. BUSCEMI , Octavian IANCEA
发明人： Edward M. GILLIS , John H. SHADDUCK , Csaba TRUCKAI , Andrew POUTIATINE , Paul J. BUSCEMI , Octavian IANCEA
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： A method of maintaining airway patency in an airway of a patient. The method includes the steps of implanting a device into airway-forming tissue without affixing the device to the tissue and permitting a bioerodable portion of the device to bioerode to apply a force to the airway-forming tissue to maintain airway patency. The invention also provides devices for practicing the method.
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公开(公告)号：US20120138069A1
公开(公告)日：2012-06-07
申请号：US13311460
申请日：2011-12-05
IPC分类号： A61F5/56
CPC分类号： A61F5/566
摘要： An implant for treating an obstructive airway disorder includes an elongate implant body configured for implanting in airway-interface tissue. At least a portion of the elongate body carries a light transmission material for permitting light transmission therein. Systems and methods of treating an airway disorder comprising implanting an implant in an airway-interface tissue are also provided.
摘要翻译： 用于治疗阻塞性气道障碍的植入物包括构造成用于植入气道界面组织中的细长植入体。 细长体的至少一部分携带用于允许光透射的透光材料。 还提供了治疗气道障碍的系统和方法，包括将植入物植入气道界面组织中。
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公开(公告)号：US20140000631A1
公开(公告)日：2014-01-02
申请号：US13539081
申请日：2012-06-29
申请人： Edward M. GILLIS , Csaba TRUCKAI , Paul J. Buscemi
发明人： Edward M. GILLIS , Csaba TRUCKAI , Paul J. Buscemi
CPC分类号： A61F5/566 , A61F2/00 , A61F2210/0004 , A61F2250/0018 , Y10T29/49826
摘要： Methods of maintaining airway patency in an airway of a patient. A method includes the steps of wrapping a bioerodable material at least partway around an axis to create a wound bioerodable implant, and coupling two points on the bioerodable material to each other. The invention also provides systems for maintaining airway patency in an airway of a patient that may be used with the methods.
摘要翻译： 维持患者气道通气通畅的方法。 一种方法包括以下步骤：将至少一部分可生物侵蚀的材料缠绕在轴线周围以产生缠绕的可生物侵蚀的植入物，并将可生物侵蚀的材料上的两个点彼此连接。 本发明还提供了可以与该方法一起使用的用于维持患者气道中的气道通畅的系统。
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公开(公告)号：US20160310314A1
公开(公告)日：2016-10-27
申请号：US15198826
申请日：2016-06-30
申请人： Edward M. GILLIS , John H. SHADDUCK
发明人： Edward M. GILLIS , John H. SHADDUCK
IPC分类号： A61F5/56
CPC分类号： A61F5/56 , A61F2/00 , A61F5/566 , A61F2210/0004
摘要： A system for revisably treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, first and second openings extend through first and second implant ends, respectively, for permitting a tissue plug to grow through each opening. Methods of using and revising such systems are also provided.
摘要翻译： 提供了一种用于可修复地治疗气道障碍的系统，植入体被构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。 在一些实施例中，第一和第二开口分别延伸穿过第一和第二植入端，以允许组织塞通过每个开口生长。 还提供了使用和修改这种系统的方法。
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公开(公告)号：US20140261451A1
公开(公告)日：2014-09-18
申请号：US14289475
申请日：2014-05-28
申请人： Edward M. GILLIS , John H. SHADDUCK
发明人： Edward M. GILLIS , John H. SHADDUCK
IPC分类号： A61F5/56
CPC分类号： A61F5/56 , A61F2/00 , A61F5/566 , A61F2210/0004
摘要： A system for revisably treating an airway disorder is provided with an implant body configured to conform to an airway-interface tissue site in a manner compatible with normal physiological function of the site. In some embodiments, first and second openings extend through first and second implant ends, respectively, for permitting a tissue plug to grow through each opening. Methods of using and revising such systems are also provided.
摘要翻译： 提供了一种用于可修复地治疗气道障碍的系统，植入体被构造成以与该部位的正常生理功能相适应的方式与气道界面组织部位一致。 在一些实施例中，第一和第二开口分别延伸穿过第一和第二植入端，以允许组织塞通过每个开口生长。 还提供了使用和修改这种系统的方法。
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公开(公告)号：US20170065452A1
公开(公告)日：2017-03-09
申请号：US15354594
申请日：2016-11-17
申请人： Edward M. GILLIS
发明人： Edward M. GILLIS
IPC分类号： A61F5/56
摘要： The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material. The deformable portion of the device has a preferred shape that corresponds to the desired final shape of the device once placed in an airway. In making a transplant-ready device, however, the deformable portion is placed into a deformed shape and constrained in that shape by the bioerodible material. After implantation, the device gradually assumes the preferred shape as the constraining bioerodible material erodes. As the device gradually reforms toward the preferred shape, it reforms the tissue into the therapeutically desirable configuration. The gradual nature of the shape change generally stabilizes the device in the tissue, and supports tissue reforming into a stable configuration.
摘要翻译： 本发明涉及用于重组患有阻塞性睡眠呼吸暂停的受试者的气道周围的组织以便打开气道并减轻呼吸暂停事件的发生的装置和方法。 装置包括可弹性变形材料和生物可腐蚀材料的组合。 装置的可变形部分具有对应于一旦放置在气道中的装置的期望最终形状的优选形状。 然而，在制造移植就绪装置中，可变形部分被放置成变形的形状并且被生物可腐蚀的材料限制在该形状中。 植入后，随着约束生物可侵蚀材料侵蚀，装置逐渐呈现出优选的形状。 随着装置逐渐改变为优选的形状，它将组织改造成治疗期望的构型。 形状变化的逐渐性质通常使组织中的装置稳定，并支持组织重整成稳定的构型。
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公开(公告)号：US20150202074A1
公开(公告)日：2015-07-23
申请号：US14674986
申请日：2015-03-31
申请人： Edward M. GILLIS , Octavian IANCEA
发明人： Edward M. GILLIS , Octavian IANCEA
IPC分类号： A61F5/56
摘要： A method of maintaining airway patency in an airway of a patient which includes the steps of implanting a device into tissue adjacent an airway, the device having a bioerodable material wound around a resiliently deformable body to temporarily maintain the deformable body in a stretched, deformed state, and permitting the bioerodable material of the device to bioerode to apply a force to maintain airway patency. The invention also provides devices for practicing the method.
摘要翻译： 一种在患者气道中保持气道通畅的方法，其包括将装置植入邻近气道的组织中的步骤，所述装置具有缠绕在弹性可变形体上的生物可蚀塑料，以暂时将变形体保持在拉伸变形状态 并且允许该装置的生物可蚀塑料进行生化代谢以施加力以维持气道通畅。 本发明还提供了用于实施该方法的装置。
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10.发明申请公开(公告)号：US20140251344A1
公开(公告)日：2014-09-11
申请号：US14282943
申请日：2014-05-20
申请人： Edward M. GILLIS
发明人： Edward M. GILLIS
IPC分类号： A61F5/56
摘要： The invention relates to devices and methods for reforming tissue surrounding the airway of a subject suffering from obstructive sleep apnea so as to open the airway and alleviate the occurrence of apneic events. Devices comprise a combination of resiliently deformable material and bioerodible material. The deformable portion of the device has a preferred shape that corresponds to the desired final shape of the device once placed in an airway. In making a transplant-ready device, however, the deformable portion is placed into a deformed shape and constrained in that shape by the bioerodible material. After implantation, the device gradually assumes the preferred shape as the constraining bioerodible material erodes. As the device gradually reforms toward the preferred shape, it reforms the tissue into the therapeutically desirable configuration. The gradual nature of the shape change generally stabilizes the device in the tissue, and supports tissue reforming into a stable configuration.
摘要翻译： 本发明涉及用于重组患有阻塞性睡眠呼吸暂停的受试者的气道周围的组织以便打开气道并减轻呼吸暂停事件的发生的装置和方法。 装置包括可弹性变形材料和生物可腐蚀材料的组合。 装置的可变形部分具有对应于一旦放置在气道中的装置的期望最终形状的优选形状。 然而，在制造移植就绪装置中，可变形部分被放置成变形的形状并且被生物可腐蚀的材料限制在该形状中。 植入后，随着约束生物可侵蚀材料侵蚀，装置逐渐呈现出优选的形状。 随着装置逐渐改变为优选的形状，它将组织改造成治疗期望的构型。 形状变化的逐渐性质通常使组织中的装置稳定，并支持组织重整成稳定的构型。
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