公开(公告)号：US20120329840A1

公开(公告)日：2012-12-27

申请号：US13605561

申请日：2012-09-06

申请人： Edward Roberts ,  Hugh Rose ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

发明人： Edward Roberts ,  Hugh Rose ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

IPC分类号： A61K31/4245 ,  A61P11/00 ,  A61P37/06 ,  C07D271/06 ,  A61P25/00

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

公开(公告)号：US08466183B2

公开(公告)日：2013-06-18

申请号：US13605427

申请日：2012-09-06

申请人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

发明人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

IPC分类号： A61K31/4245 ,  C07D271/06

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds of the following generic structure are provided: Such compounds activate a sphingosine-I-phosphate receptor of the subtype 1 (S1P1), and have utility in the treatment of malconditions mediated by S1P1 activation. More specifically, such compounds are beneficial in the treatment of, for example, multiple sclerosis, transplant rejection and/or adult respiratory syndrome.

公开(公告)号：US20150057307A1

公开(公告)日：2015-02-26

申请号：US14311825

申请日：2014-06-23

申请人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

发明人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

IPC分类号： C07D471/04 ,  C07D263/32 ,  C07D401/04 ,  C07D271/06 ,  C07D413/04 ,  C07D413/14

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

摘要翻译： 提供激活亚型1的鞘氨醇-1-磷酸受体的化合物。 某些化合物选择性地激活了关于鞘氨醇 - 1-磷酸受体亚型3的受体亚型1。本发明化合物的用途和方法用于治疗病症，其中在医学上指示S1P1的活化，激动，抑制或拮抗作用。

公开(公告)号：US08481573B2

公开(公告)日：2013-07-09

申请号：US13605561

申请日：2012-09-06

申请人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

发明人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

IPC分类号： A61K31/4245 ,  C07D271/06

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds of the following generic structure are provided: Such compounds activate a sphingosine-I-phosphate receptor of the subtype 1 (S1P1), and have utility in the treatment of malconditions mediated by S1P1 activation. More specifically, such compounds are beneficial in the treatment of, for example, multiple sclerosis, transplant rejection and/or adult respiratory syndrome.

公开(公告)号：US20120329839A1

公开(公告)日：2012-12-27

申请号：US13605427

申请日：2012-09-06

申请人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

发明人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

IPC分类号： A61K31/4245 ,  A61P11/00 ,  A61P37/06 ,  C07D271/06 ,  A61P25/00

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

摘要翻译： 提供激活亚型1的鞘氨醇-1-磷酸受体的化合物。 某些化合物选择性地激活了关于鞘氨醇 - 1-磷酸受体亚型3的受体亚型1。本发明化合物的用途和方法用于治疗病症，其中在医学上指示S1P1的活化，激动，抑制或拮抗作用。

公开(公告)号：US08530503B2

公开(公告)日：2013-09-10

申请号：US13605358

申请日：2012-09-06

申请人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

发明人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

IPC分类号： A61K31/4245 ,  C07D271/06

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds of the following generic structure are provided: Such compounds activate a sphingosine-I-phosphate receptor of the subtype 1 (S1P1), and have utility in the treatment of malconditions mediated by S1P1 activation. More specifically, such compounds are beneficial in the treatment of, for example, multiple sclerosis, transplant rejection and/or adult respiratory syndrome.

摘要翻译： 提供以下通用结构的化合物：这样的化合物活化亚型1（S1P1）的鞘氨醇-1-磷酸受体，并且可用于治疗由S1P1活化介导的病态。 更具体地，这些化合物有益于治疗例如多发性硬化，移植排斥和/或成人呼吸综合征。

公开(公告)号：US20120329838A1

公开(公告)日：2012-12-27

申请号：US13605358

申请日：2012-09-06

申请人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

发明人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

IPC分类号： C07D271/06 ,  A61P37/06 ,  A61P25/00 ,  A61P11/00 ,  A61K31/4245 ,  C12N5/071

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

公开(公告)号：US08796318B2

公开(公告)日：2014-08-05

申请号：US12465767

申请日：2009-05-14

申请人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

发明人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

IPC分类号： A61K31/4245 ,  C07D271/06

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

摘要翻译： 提供激活亚型1的鞘氨醇-1-磷酸受体的化合物。 某些化合物选择性地激活了关于鞘氨醇 - 1-磷酸受体亚型3的受体亚型1。本发明化合物的用途和方法用于治疗病症，其中在医学上指示S1P1的活化，激动，抑制或拮抗作用。

公开(公告)号：US20100010001A1

公开(公告)日：2010-01-14

申请号：US12465767

申请日：2009-05-14

申请人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

发明人： Edward Roberts ,  Hugh Rosen ,  Steven Brown ,  Miguel A. Guerrero ,  Xuemei Peng ,  Ramulu Poddutoori

IPC分类号： A61K31/506 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/4245 ,  C07D413/00 ,  C07D271/06

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-4-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

摘要翻译： 提供激活亚型1的鞘氨醇-1-磷酸受体的化合物。 某些化合物选择性地激活相关于鞘氨醇-4-磷酸受体亚型3的受体亚型1。本发明化合物的用途和方法用于治疗其中药学上指示S1P1的活化，激动，抑制或拮抗作用的病症。

公开(公告)号：US11454196B1

公开(公告)日：2022-09-27

申请号：US12150765

申请日：2008-04-30

申请人： Steven Brown

发明人： Steven Brown

IPC分类号： F02M21/04 ,  F02M21/02

摘要： A fuel bowl is disclosed. The fuel bowl comprises a body having an interior opposite an exterior, four sides, and a bottom opposite an opening. The opening is configured to be in fluid communication with a carburetor or an adaptor. The fuel bowl also comprises a fuel inlet port disposed in at least one of the four sides and configured to receive a gaseous fuel from a fuel regulator. The gaseous fuel expands and contracts within the body. A carburetor system is also disclosed. The carburetor system comprises a gaseous fuel, a fuel regulator configured to receive and deliver the gaseous fuel, a fuel bowl in fluid communication with the fuel regulator and a carburetor, a final fuel metering restriction disposed in an inlet supply port of a cylinder of the carburetor, and a venturi disposed in the carburetor.