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公开(公告)号：US20120308540A1
公开(公告)日：2012-12-06
申请号：US13373118
申请日：2011-11-03
IPC分类号： C12N9/64 , C12N15/57 , C12N15/63 , A61K35/18 , C12N5/10 , A61K38/48 , A61P7/04 , A61K35/14 , C12N9/96 , C12N15/79
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰因子IX（FIX）多肽及其用途。 这种修饰的FIX多肽包括FIXa和其它形式的FIX。 提供的修饰的FIX多肽中的那些是具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US09328339B2
公开(公告)日：2016-05-03
申请号：US14267754
申请日：2014-05-01
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
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公开(公告)号：US20140322191A1
公开(公告)日：2014-10-30
申请号：US14267754
申请日：2014-05-01
IPC分类号： C12N9/64
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰因子IX（FIX）多肽及其用途。 这种修饰的FIX多肽包括FIXa和其它形式的FIX。 提供的修饰的FIX多肽中的那些是具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US08778870B2
公开(公告)日：2014-07-15
申请号：US13373118
申请日：2011-11-03
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰因子IX（FIX）多肽及其用途。 这种修饰的FIX多肽包括FIXa和其它形式的FIX。 提供的修饰的FIX多肽中的那些是具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US20130177541A9
公开(公告)日：2013-07-11
申请号：US13373118
申请日：2011-11-03
IPC分类号： C12N9/64 , C12N15/57 , C12N15/63 , A61K35/18 , C12N5/10 , A61K38/48 , A61P7/04 , A61K35/14 , C12N9/96 , C12N15/79
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰因子IX（FIX）多肽及其用途。 这种修饰的FIX多肽包括FIXa和其它形式的FIX。 提供的修饰的FIX多肽中的那些是具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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