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公开(公告)号：US20140234290A1
公开(公告)日：2014-08-21
申请号：US14244840
申请日：2014-04-03
CPC分类号： C12N9/6432 , A61K38/36 , A61K38/482 , A61K38/4846
摘要： Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided.
摘要翻译： 提供了修饰的治疗蛋白质。 提供了包括因子X酶原，因子Xa和其他形式的因子X的修饰的因子X多肽及其用途。
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公开(公告)号：US20110177025A1
公开(公告)日：2011-07-21
申请号：US13054428
申请日：2009-07-15
申请人： Christopher Thanos , Briannan Bintz
发明人： Christopher Thanos , Briannan Bintz
IPC分类号： A61K38/20 , A61K38/00 , A61K38/18 , A61K38/30 , A61K38/16 , A61K38/29 , A61K38/14 , A61K38/31 , A61K35/12 , C12N5/07 , A61K8/64 , A61P17/02 , A61Q19/00
CPC分类号： A61K35/30 , A61K8/11 , A61K8/64 , A61K8/733 , A61K8/981 , A61K9/0014 , A61K9/0019 , A61K9/1647 , A61K9/19 , A61K9/5036 , A61K31/203 , A61K38/18 , A61K38/19 , A61K38/31 , A61K45/06 , A61K2800/412 , A61Q7/00 , A61Q19/00 , A61K2300/00
摘要： The invention relates to methods and compositions for improving wound healing and in particular for preventing scar formation and thus loss of function that can occur in injured tissues during the natural wound healing process. Particularly, although by no means exclusively, the invention relates to the healing of chronic wounds such as diabetic ulcers.
摘要翻译： 本发明涉及用于改善伤口愈合的方法和组合物，特别是用于防止在自然伤口愈合过程中损伤的组织中可能发生的瘢痕形成和因此丧失功能。 特别地，尽管绝不是专门，本发明涉及慢性伤口如糖尿病性溃疡的愈合。
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公开(公告)号：US20110166218A1
公开(公告)日：2011-07-07
申请号：US12140701
申请日：2008-06-17
申请人： Edith Mathiowitz , Christopher Thanos , Zhi Liu
发明人： Edith Mathiowitz , Christopher Thanos , Zhi Liu
IPC分类号： A61K31/352 , B29B9/12 , A61K31/337 , A61P3/10 , A61P31/10 , A61P9/12 , A61P31/00 , A61P35/00 , A61P25/08 , A61P25/18 , A61P19/02 , A61P31/12 , A61P37/02
CPC分类号： A61K9/5138 , A61K9/14 , A61K9/146 , A61K9/1688 , A61K9/1694 , A61K9/5146 , A61K9/5192 , B01D9/00 , B01J13/06 , Y10T428/2982 , Y10T428/2985 , Y10T428/2989 , Y10T428/31685 , Y10T428/31696
摘要： The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.
摘要翻译： 本发明涉及与疏水性药物的微粉化相关的方法和产品。 提供了使用一组包括水溶液的溶液来微粉化疏水性药物的方法。 本发明还涉及微粉化疏水药物的产品和相关使用方法。
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公开(公告)号：US20120308540A1
公开(公告)日：2012-12-06
申请号：US13373118
申请日：2011-11-03
IPC分类号： C12N9/64 , C12N15/57 , C12N15/63 , A61K35/18 , C12N5/10 , A61K38/48 , A61P7/04 , A61K35/14 , C12N9/96 , C12N15/79
CPC分类号： C12N9/644 , A61K38/4846 , A61K48/00 , C12Y304/21022
摘要： Modified Factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other forms of FIX. Among the modified FIX polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰因子IX（FIX）多肽及其用途。 这种修饰的FIX多肽包括FIXa和其它形式的FIX。 提供的修饰的FIX多肽中的那些是具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US20090098103A1
公开(公告)日：2009-04-16
申请号：US12082662
申请日：2008-04-11
CPC分类号： C07K14/745 , A61K38/00 , A61K38/36 , A61K45/06 , A61K2300/00
摘要： Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
摘要翻译： 提供了修饰的因子VII多肽及其用途。 这种修饰的FVII多肽包括因子VIIa和其他形式的因子VII。 所提供的经修饰的FVII多肽是那些具有改变的活性，通常改变的促凝活性，包括增加的促凝活性。 因此，这些修饰的多肽是治疗剂。
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公开(公告)号：US20080286864A1
公开(公告)日：2008-11-20
申请号：US11911961
申请日：2006-04-18
申请人： Robert Bartlett Elliott , Stephen John Martin Skinner , Livia Del Carmen Escobar Orellana , Christopher Thanos
发明人： Robert Bartlett Elliott , Stephen John Martin Skinner , Livia Del Carmen Escobar Orellana , Christopher Thanos
IPC分类号： C12N5/02
CPC分类号： C12N5/0018 , C12N2502/08
摘要： The present invention is directed to the use of choroid plexus cells and/or choroid plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.
摘要翻译： 本发明涉及脉络丛神经细胞和/或脉络丛条件培养基用于增强长期或短期培养中生长的非脉络丛神经细胞的生长，存活和/或维持功能的用途。
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公开(公告)号：US20050100595A1
公开(公告)日：2005-05-12
申请号：US11002842
申请日：2004-11-30
申请人： Edith Mathiowitz , Christopher Thanos , Zhi Liu
发明人： Edith Mathiowitz , Christopher Thanos , Zhi Liu
IPC分类号： A23P1/02 , A23P1/06 , A61K9/14 , A61K9/16 , A61K9/51 , A61K9/52 , B01D9/00 , B01D9/02 , B01J13/04 , B01J13/06 , B01J13/14 , A61K9/54
CPC分类号： A61K9/5138 , A61K9/14 , A61K9/146 , A61K9/1688 , A61K9/1694 , A61K9/5146 , A61K9/5192 , B01D9/00 , B01J13/06 , Y10T428/2982 , Y10T428/2985 , Y10T428/2989 , Y10T428/31685 , Y10T428/31696
摘要： The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.
摘要翻译： 本发明涉及与疏水性药物的微粉化相关的方法和产品。 提供了使用一组包括水溶液的溶液来微粉化疏水性药物的方法。 本发明还涉及微粉化疏水药物的产品和相关使用方法。
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公开(公告)号：US06746635B2
公开(公告)日：2004-06-08
申请号：US10215208
申请日：2002-08-08
申请人： Edith Mathiowitz , Christopher Thanos , Zhi Liu
发明人： Edith Mathiowitz , Christopher Thanos , Zhi Liu
IPC分类号： B01J1302
CPC分类号： A61K9/5138 , A61K9/14 , A61K9/146 , A61K9/1688 , A61K9/1694 , A61K9/5146 , A61K9/5192 , B01D9/00 , B01J13/06 , Y10T428/2982 , Y10T428/2985 , Y10T428/2989 , Y10T428/31685 , Y10T428/31696
摘要： The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydrophobic drugs and related methods of use.
摘要翻译： 本发明涉及与疏水性药物的微粉化相关的方法和产品。 提供了使用一组包括水溶液的溶液来微粉化疏水性药物的方法。 本发明还涉及微粉化疏水药物的产品和相关使用方法。
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公开(公告)号：US20140242062A1
公开(公告)日：2014-08-28
申请号：US14275772
申请日：2014-05-12
IPC分类号： A61K38/48
CPC分类号： A61K38/482 , A61K38/49 , C07K2319/00 , C12N9/6421 , C12N9/6424 , C12N9/6467 , C12Y304/21109
摘要： Provided are methods for and compounds for modulating the complement system. In particular, compounds are provided that inhibit complement activation and compounds are provided that promote complement activation. The compounds are therapeutics by virtue of their effects on the complement system. Hence, the compounds that inhibit complement activation can be used for treatment of ischemic and reperfusion disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, including Alzheimer's Disease and other neurodegenerative disorders.
摘要翻译： 提供了用于调节补体系统的方法和化合物。 特别地，提供抑制补体活化的化合物，并提供促进补体活化的化合物。 这些化合物由于其对补体系统的作用而成为治疗剂。 因此，抑制补体活化的化合物可用于治疗缺血和再灌注障碍，包括心肌梗死和中风，败血症，自身免疫性疾病，炎症性疾病和具有炎性成分的疾病，包括阿尔茨海默病和其他神经变性疾病。
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公开(公告)号：US08519103B2
公开(公告)日：2013-08-27
申请号：US12384915
申请日：2009-04-10
IPC分类号： A61K38/36 , C07K14/745 , A61P7/04
CPC分类号： C12N9/6437 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N15/62 , C12Y304/21021
摘要： Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor VIIa and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.
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