公开(公告)号：US11826399B2

公开(公告)日：2023-11-28

申请号：US16646998

申请日：2018-09-14

申请人： Eisai Inc.

发明人： Sharon McGonigle ,  Utpal Majumder ,  Maarten H. D. Postema

IPC分类号： A61K38/17 ,  A61K47/68 ,  A61P35/00 ,  A61K31/337 ,  A61K45/06 ,  A61K49/00

CPC分类号： A61K38/1767 ,  A61K31/337 ,  A61K45/06 ,  A61K47/6817 ,  A61K49/0019 ,  A61K49/0026 ,  A61K49/0065 ,  A61P35/00

摘要： The present invention provides, among other things, compositions and methods relating to detection and/or treatment cancer (e.g., one or more tumors) that expresses Neuropilin 1 (NRP1). The present invention provides methods of treating cancer that include administering a chlorotoxin agent to a subject (e.g., to a subject suffering from or susceptible to the cancer which may, in some embodiments, be a cancer that expresses NRP1). In some embodiments, a chlorotoxin agent for use in accordance with the present invention can be or comprise a chlorotoxin polypeptide and a payload moiety (e.g., as a covalent conjugate).

公开(公告)号：US20200206312A1

公开(公告)日：2020-07-02

申请号：US16646998

申请日：2018-09-14

申请人： Eisai Inc.

发明人： Sharon McGonigle ,  Utpal Majumder ,  Maarten H. D. Postema

IPC分类号： A61K38/17 ,  A61K45/06 ,  A61K31/337 ,  A61K47/68 ,  A61K49/00 ,  A61P35/00

摘要： The present invention provides, among other things, compositions and methods relating to detection and/or treatment cancer (e.g., one or more tumors) that expresses Neuropilin 1 (NRP1). The present invention provides methods of treating cancer that include administering a chlorotoxin agent to a subject (e.g., to a subject suffering from or susceptible to the cancer which may, in some embodiments, be a cancer that expresses NRP1). In some embodiments, a chlorotoxin agent for use in accordance with the present invention can be or comprise a chlorotoxin polypeptide and a payload moiety (e.g., as a covalent conjugate).