公开(公告)号：US11160783B2

公开(公告)日：2021-11-02

申请号：US15960259

申请日：2018-04-23

Applicant: Eisai R&D Management Co., LTD.

Inventor： Sergei Agoulnik ,  Bruce Decosta ,  Hong Du ,  Yimin Jiang ,  Xiang-Yi Li ,  Kenichi Nomoto ,  John (Yuan) Wang ,  Huiming Zhang

IPC: A61K31/365 ,  A61P35/00 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/665 ,  A61K45/06

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

公开(公告)号：US20180353468A1

公开(公告)日：2018-12-13

申请号：US15960259

申请日：2018-04-23

Applicant: Eisai R&D Management Co., LTD.

Inventor： Sergei Agoulnik ,  Bruce Decosta ,  Hong Du ,  Yimin Jiang ,  Xiang-Yi Li ,  Kenichi Nomoto ,  John (Yuan) Wang ,  Huiming Zhang

IPC: A61K31/365 ,  A61K45/06 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/665 ,  A61K31/4523

CPC classification number: A61K31/365 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/665 ,  A61K45/06

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

公开(公告)号：US08937056B2

公开(公告)日：2015-01-20

申请号：US13794635

申请日：2013-03-11

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Sergei Agoulnik ,  Bruce Decosta ,  Hong Du ,  Yimin Jiang ,  Xiang-Yi Li ,  Kenichi Nomoto ,  John (Yuan) Wang ,  Huiming Zhang

IPC: A01N57/00 ,  A61K31/665 ,  A01N43/02 ,  A61K31/335 ,  A01N43/76 ,  A61K31/42 ,  A61K31/415 ,  A61K31/497 ,  A61K31/535 ,  A61K31/4178 ,  A61K31/365 ,  A61K31/422 ,  A61K31/5377 ,  A61K45/06 ,  A61K31/496 ,  A61K31/4025 ,  A61K31/4523

CPC classification number: A61K31/365 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/665 ,  A61K45/06

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract translation: 本发明提供了用于治疗特定癌症的化合物，药物组合物和方法。 这样的组合物通常可以包含式（I）的化合物：其中R 1 -R 3如本文所定义，或其药学上可接受的盐或酯; 和药学上可接受的载体。

公开(公告)号：US20150182496A1

公开(公告)日：2015-07-02

申请号：US14595746

申请日：2015-01-13

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Sergei Agoulnik ,  Bruce Decosta ,  Hong Du ,  Yimin Jiang ,  Xiang-Yi Li ,  Kenichi Nomoto ,  John (Yuan) Wang ,  Huiming Zhang

IPC: A61K31/365 ,  A61K31/496 ,  A61K45/06 ,  A61K31/4025 ,  A61K31/422 ,  A61K31/665 ,  A61K31/4178 ,  A61K31/5377

CPC classification number: A61K31/365 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/4523 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/665 ,  A61K45/06

Abstract: The present invention provides compounds, pharmaceutical compositions and methods for the treatment of specific cancers. Such compositions may generally comprise a compound of formula (I): wherein R1-R3 are as defined herein, or pharmaceutically acceptable salts or esters thereof; and a pharmaceutically acceptable carrier.

Abstract translation: 本发明提供了用于治疗特定癌症的化合物，药物组合物和方法。 这样的组合物通常可以包含式（I）的化合物：其中R 1 -R 3如本文所定义，或其药学上可接受的盐或酯; 和药学上可接受的载体。

公开(公告)号：US09549922B2

公开(公告)日：2017-01-24

申请号：US14315930

申请日：2014-06-26

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Kenichi Nomoto ,  Jiayi Wu

IPC: A61K31/47 ,  A61K31/357

CPC classification number: A61K31/47 ,  A61K31/357 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention provides methods and compositions for use in treating diseases associated with excessive cellular proliferation, such as cancer.

Abstract translation: 本发明提供了用于治疗与过度细胞增殖相关的疾病如癌症的方法和组合物。