公开(公告)号：US20170298078A1

公开(公告)日：2017-10-19

申请号：US15638493

申请日：2017-06-30

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Yongbo HU ,  Huiming ZHANG ,  Hiroyuki CHIBA ,  Yuki KOMATSU ,  Bryan M. LEWIS

IPC: C07D493/22

CPC classification number: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：US20150158881A1

公开(公告)日：2015-06-11

申请号：US14562086

申请日：2014-12-05

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yongbo HU ,  Huiming ZHANG ,  Hiroyuki CHIBA ,  Yuki KOMATSU ,  Bryan M. LEWIS

IPC: C07D493/22

CPC classification number: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

Abstract translation: 通常，本发明的特征在于可用于合成软骨素B类似物的改进方法，例如胡椒素及其药学上可接受的盐（例如，甲磺酸eribulin）。

公开(公告)号：US20140221635A1

公开(公告)日：2014-08-07

申请号：US14250086

申请日：2014-04-10

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. FANG ,  Bryan M. LEWIS ,  Matthew SCHNADERBECK

IPC: C07D493/20 ,  C07D493/10 ,  C07H15/26 ,  C07D317/72

CPC classification number: C07F7/1804 ,  A61K31/341 ,  C07C33/423 ,  C07D307/12 ,  C07D307/28 ,  C07D307/33 ,  C07D317/72 ,  C07D407/06 ,  C07D407/14 ,  C07D493/04 ,  C07D493/08 ,  C07D493/10 ,  C07D493/18 ,  C07D493/20 ,  C07D493/22 ,  C07F7/188 ,  C07H15/26 ,  Y02P20/55

Abstract: Intermediates and methods of their use in the synthesis of anslogs of halichondrin B are provided.

Abstract translation: 提供了中间体及其在软骨素B的合成中的应用。

公开(公告)号：US20190010166A1

公开(公告)日：2019-01-10

申请号：US16031629

申请日：2018-07-10

Applicant: EISAI R&D MANAGEMENT CO., LTD.

Inventor： Yongbo HU ,  Huiming ZHANG ,  Hiroyuki CHIBA ,  Yuki KOMATSU ,  Bryan M. LEWIS

IPC: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

公开(公告)号：US20160176895A1

公开(公告)日：2016-06-23

申请号：US15059965

申请日：2016-03-03

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Yongbo HU ,  Huiming ZHANG ,  Hiroyuki CHIBA ,  Yuki KOMATSU ,  Bryan M. LEWIS

IPC: C07D493/22

CPC classification number: C07D493/22

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).