公开(公告)号：US11026944B2

公开(公告)日：2021-06-08

申请号：US16819341

申请日：2020-03-16

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Margaret Moline ,  Gina Pastino ,  Yurie Akimoto ,  Yasuhiro Zaima ,  Nobuya Suzuki ,  Nobuo Yoshida

IPC: A61K31/506 ,  A61K9/48 ,  A61K9/00 ,  A61K9/20

Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.

公开(公告)号：US10702529B2

公开(公告)日：2020-07-07

申请号：US16255116

申请日：2019-01-23

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Margaret Moline ,  Gina Pastino ,  Yurie Akimoto ,  Yasuhiro Zaima ,  Nobuya Suzuki ,  Nobuo Yoshida

IPC: A61K31/506 ,  A61K9/48 ,  A61K9/00 ,  A61K9/20

Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.

公开(公告)号：US10188652B2

公开(公告)日：2019-01-29

申请号：US15519676

申请日：2015-10-21

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Margaret Moline ,  Gina Pastino ,  Yurie Akimoto ,  Yasuhiro Zaima ,  Nobuya Suzuki ,  Nobuo Yoshida

IPC: A61K31/506 ,  A61K9/00 ,  A61K9/20 ,  A61K9/48

Abstract: In the present invention, compound such as (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide have been found to be potent orexin receptor antagonists, and may be useful in the treatment of sleep disorders such as insomnia, as well as for other therapeutic uses.